JOURNAL OF PRACTICAL ELECTROCARDIOLOGY

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JOURNAL OF PRACTICAL ELECTROCARDIOLOGY

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JOURNAL OF PRACTICAL ELECTROCARDIOLOGY

	2024 Vol.33 Issue.6 Published 2024-12-28

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		2024 Vol. 33 (6): 538-538 [Abstract] ( 0 ) [HTML 1KB] [ PDF 116465KB] ( 3 )

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		2024 Vol. 33 (6): 539-539 [Abstract] ( 0 ) [HTML 1KB] [ PDF 10957KB] ( 4 )

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		2024 Vol. 33 (6): 540-540 [Abstract] ( 0 ) [HTML 1KB] [ PDF 898KB] ( 3 )

	541	Pay attention to diagnosis and treatment of cardiovascular adverse reactions associated with immune checkpoint inhibitors
		ZHAN Hongji, LIU Hongxia, TAN Mengqin，WANG Fujun
		Immune checkpoint inhibitors (ICIs) occupy a core position in tumor immunotherapy, and greatly improve the prognosis of tumor patients. However, with the deepening of clinical practice, it has been found that ICIs can not only activate the immune system, but also cause many adverse reactions, especially leading to a variety of cardiovascular toxicity and increased cardiovascular mortality. This paper reviews the clinical manifestations, pathogenesis, diagnosis and treatment, etc. of ICIsinduced cardiovascular toxicity, which provides evidences for preventing cardiovascular injury and improving cardiac function.
		2024 Vol. 33 (6): 541-547 [Abstract] ( 0 ) [HTML 1KB] [ PDF 1233KB] ( 4 )

	548	Advances in diagnosis and treatment of myocarditis caused by immune checkpoint inhibitors
		TAN Mengqin, LUO Dan, ZHANG Zhou, WANG Fujun
		With the wide application of immune checkpoint inhibitors (ICIs) in the field of tumor treatment, a series of immunerelated adverse reactions of cardiovascular system caused by ICIs have aroused clinicians attention. ICIsassociated myocarditis has become a focus due to its relatively low incidence but high lethality. At present, we have not known enough about the molecular mechanism and pathophysiological process of ICIsinduced myocarditis. This paper explores the pathological mechanisms of ICIsassociated myocarditis, its risk factors, clinical features, means of diagnosis and monitoring, and formulation of reasonable treatment strategies through literature review, so as to enhance clinicians alertness and ability to deal with such adverse events, and improve the prognosis of tumor patients.
		2024 Vol. 33 (6): 548-552 [Abstract] ( 0 ) [HTML 1KB] [ PDF 1088KB] ( 5 )

	553	Research advances in pericardial diseases associated with immune checkpoint inhibitors
		ZHANG Zhou, LUO Dan, TAN Mengqin, WANG Fujun
		Immune checkpoint inhibitors (ICIs) have been widely applied in the clinical treatment of various malignant tumors by blocking the tumor immune escape. However, it is followed by increasing immunerelated adverse events caused by ICIs. As common ICIsrelated cardiovascular adverse reactions, pericardial diseases lead to a relatively high mortality at the acute phase. This article introduces the research progress in recent years on the epidemiology, pathogenesis, clinical characteristics, and treatment principles of ICIsrelated pericardial diseases, in order to deepen the clinicians understandings of this disease.
		2024 Vol. 33 (6): 553-556 [Abstract] ( 0 ) [HTML 1KB] [ PDF 1026KB] ( 6 )

	557	Research advances in diagnosis and treatment of cardiomyopathy associated with immune checkpoint inhibitors
		LUO Dan, TAN Mengqin, ZHANG Zhou, WANG Fujun
		Immune checkpoint inhibitors (ICIs) have shown remarkable success in increasing tumor patients survival rates, but the increasing immunerelated adverse cardiovascular events seriously affect the treatment and prognosis of these patients. This review summarizes the latest research advances in the pathogenesis, clinical manifestations, diagnosis and treatment of ICIsrelated cardiomyopathy in order to provide references for both cardiologists and oncologists in clinical practice.
		2024 Vol. 33 (6): 557-562 [Abstract] ( 0 ) [HTML 1KB] [ PDF 1068KB] ( 5 )

	563	Research progress of arrhythmias and other electrocardiogram changes associated with immune checkpoint inhibitors
		ZHOU Fang, MI Yan, TAN Mengqin, WANG Fujun
		With the widespread application of immune checkpoint inhibitors (ICIs) in the treatment of malignant tumors, the immunerelated adverse reactions caused by ICIs have attracted extensive attention, and the cardiotoxic side effects caused by ICIs result in a relatively high risk of death. This article reviews the epidemiology, pathogenesis, some types and other ECG changes of ICIsassociated arrhythmias based on the current studies and reports.
		2024 Vol. 33 (6): 563-566 [Abstract] ( 0 ) [HTML 1KB] [ PDF 1059KB] ( 4 )

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		2024 Vol. 33 (6): 567-571 [Abstract] ( 0 ) [HTML 1KB] [ PDF 12756KB] ( 4 )

	572	Correlation between ST-segment depression, ST-T changes and atrial premature beats or premature ventricular contraction
		LI Rong, SONG Xiao, ZHAO Rui, WANG Bingling, MA Mingren
		Objective To explore the correlation between ST-segment depression, ST-T changes, and atrial premature beats (APB) or premature ventricular contraction (PVC). Methods By univariate and multivariate Logistic regression analysis, retrospective analysis was conducted on clinical ECG data to determine the relationship between ST-segment depression, ST-T changes, and APB or PVC. Results Analysis of the ECG data from 4 952 patients revealed a significant correlation of ST-segment depression and ST-T changes with APB and PVC. Among the patients with ST-segment depression, the incidences of APB and PVC separately increased to 9.00 and 13.65 times the incidences in the patients without ST-segment depression. Among the patients with ST-T changes, the incidences of APB and PVC separately increased to 27.60 and 22.00 times the incidences in the patients without ST-T changes. Multivariate Logistic regression analysis also found that ST-segment depression of up to 0.05 mV and ST-T changes were key factors influencing the occurrence of APB and PVC. Conclusion ST-segment depression and ST-T changes may serve as risk factors for the occurrence of APB and PVC.
		2024 Vol. 33 (6): 572-577 [Abstract] ( 0 ) [HTML 1KB] [ PDF 7787KB] ( 4 )

	578	Effect relationship between renal artery stenosis parameters and renovascular hypertension grading based on curved planar reformation technique
		CHEN Yun, KONG Qianqian, ZHU Yan, ZHAO Tian, LI Yuefeng
		Objective To explore the effect relationship between renal artery stenosis parameters and the grading of renovascular hypertension (RVH) by using curved planar reformation (CPR) technique. Methods The clinical and imaging data of 34 subjects specifically diagnosed with RVH were retrospectively analyzed. These patients were divided into grade 2 hypertension group (18 cases) and grade 3 hypertension group (16 cases) according to the hypertension grading standard. Another 12 subjects were enrolled as the healthy control group. The renal artery computed tomography angiography (CTA) was performed on the three groups, and the images were separately made CPR. Additionally, the morphological parameters of renal artery (the minimum pipe diameter, the minimum crosssectional area, stenosis ratio of pipe diameter and stenosis ratio of crosssectional area), and hemodynamic parameters (threshold time and bloodflow metabolic ratio) were measured. We compared the renal artery morphological and hemodynamic parameters between groups by using oneway analysis of variance. Pearson correlation analysis was used to explore the correlationship between renal artery morphological or hemodynamic parameters and blood pressure values of the subjects, while ROC curve analysis was applied to evaluate the differential diagnosis efficiency of the stenosis ratio of crosssectional area among different groups. Results Compared with the control group, the minimum pipe diameter and minimum crosssectional area of the renal artery were significantly smaller in the hypertension group, while these parameters of the grade 3 hypertension group were smaller than those of the grade 2 hypertension group (all P<0.05). Compared with the grade 2 hypertension group, the stenosis ratio of pipe diameter and stenosis ratio of crosssectional area in the grade 3 hypertension group were significantly increased (all P<0.05); the threshold time was significantly prolonged, while the bloodflow metabolic ratio significantly decreased in the grade 3 hypertension group (all P<0.05). The corrected correlation analysis revealed that the correlationship between stenosis ratio of crosssectional area and diastolic or systolic blood pressure was the most significant (r=0.663, 0.671, both P<0.01). The stenosis ratio of crosssectional area demonstrated good differential diagnosis efficiency either between the control group and the hypertension group, or between the grade 2 hypertension group and grade 3 hypertension group (AUC=0.887, P=0.014; AUC=0.818, P=0.027). Conclusion Renal artery morphological parameters (stenosis ratio of pipe diameter and stenosis ratio of crosssectional area) based on CPR technique are expected to be used as assessment and monitoring parameters for RVH.
		2024 Vol. 33 (6): 578-583 [Abstract] ( 0 ) [HTML 1KB] [ PDF 3849KB] ( 4 )

	584	Analysis on sexual differences of abnormal ECG characteristics in patients aged 90 and above
		MAIMAITIMING Muyesaier, LIU Huijuan, WANG Fangli, FENG Yan
		Objective To explore the characteristics of abnormal ECGs in elderly population aged 90 and above as well as their clinical significance. Methods A retrospective analysis was conducted on the clinical data of 204 hospitalized patients aged 90 and above. These patients were divided into two groups based on sex (114 males and 90 females). Baseline clinical data, fasting blood glucose, blood lipids, liver and kidney function, brain natriuretic peptide(BNP), ECG, and echocardiography examination results were compared and analyzed between the two groups. Results Systolic blood pressure and triglyceride levels at admission were significantly higher in the female group compared to the male group (P<0.05), while creatinine and blood urea nitrogen levels were significantly higher in the male group (P<0.05). Sinus rhythm was observed in 765% of the patients. According to the detection rate from high to low, the most common ECG abnormalities were ST-T changes (46.1%), atrial premature beats (22.1%), firstdegree atrioventricular block (22.1%), right bundle branch block (19.6%), and atrial fibrillation (13.7%) in order. The detection rates of atrial flutter, atrial premature beats, premature ventricular contraction, right bundle branch block, firstdegree atrioventricular block, and left anterior fascicular block were all higher in the male group than those in the female group. Conclusion ECG abnormalities are common in hospitalized patients aged 90 and above, primarily manifesting as ST-T changes, atrial premature beats, firstdegree atrioventricular block, right bundle branch block, and atrial fibrillation. The distribution of these ECG abnormalities differs between different sexes.
		2024 Vol. 33 (6): 584-587 [Abstract] ( 1 ) [HTML 1KB] [ PDF 1045KB] ( 4 )

	588	Rapid analysis of ambulatory electrocardiography with superposition diagram
		WANG Xiufang, SHEN Jihong, JING Yongming, LI Shifeng
		Objective To explore the principle of superposition diagram and its application in the analysis of ambulatory electrocardiography (AECG). Methods We selected 4 typical AECG cases related to morphological information (sinus rhythm and ventricular rhythm, sinus rhythm and atrial rhythm, sinus rhythm and junctional rhythm, DDD pacing mode and VAT pacing mode of dualchamber pacemaker). The principle and advantages of superposition diagram were analyzed, and summarized in combination with Lorenz scattered plot, ECG waterfall diagram and reverse technique. Results Ventricular rhythm showed a wide QRS complex pattern, while sinus rhythm was manifested by a narrow QRS complex pattern; the above two rhythms could be separated rapidly by superposition diagram. The sinus rhythm showed upright Pwave, while atrial rhythm showed inverted Pwave; the above two rhythms could be quickly separated by superposition diagram. The sinus rhythm showed upright Pwave, while the junctional rhythm showed no Pwave; the above two rhythms could be separated quickly by superposition diagram. In the DDD pacing mode of dualchamber pacemaker, the double pulses of AP and VP could be observed, while the single pulse of VP appeared in the VAT pacing mode; the two kinds of pacing modes could be quickly separated by superposition diagram. Conclusion The superposition diagram has unique advantages in the analysis of AECGs with morphological information changes, and it is another efficient tool for rapid analysis of AECGs.
		2024 Vol. 33 (6): 588-594 [Abstract] ( 0 ) [HTML 1KB] [ PDF 24822KB] ( 5 )

	595	Clinical analysis and application of critical values in ambulatory electrocardiography based on electrocardiogram network system
		FENG Yan, TUERXUN Maiwujiudai, MAIMAITI Aerzuguli
		Objective To explore the clinical application value of critical value reporting of ambulatory electrocardiography (AECG). Methods We enrolled 69 053 patients who had undergone AECG examination in the study, among whom a total of 376 patients with critical value reports were detected. A retrospective analysis was conducted on the detected AECG critical value reports to summarize their clinical application value. Results Out of 376 AECG critical value reports, there were 65 outpatients and 311 hospitalized patients. AECG critical value reports usually occurred in the elderly population aged 60 and above. The incidences of acute coronary syndrome and severe bradycardia were the highest in the five major categories of AECG critical values; among 13 subtypes of AECG critical values, the incidences of suspected myocardial ischemia or injury, and long PP interval of 3-5 seconds were the highest. The incidences of acute coronary syndrome and severe tachyarrhythmia were higher in male patients than those in female patients, while the incidences of severe bradycardia and significantly prolonged QT interval were higher in female patients than those in male patients, all with statistically significant differences (all P<0.05). The reports of the 13 subtypes of AECG critical values mainly originated from the outpatient and neurology departments (inpatient). Conclusion The critical values of AECG are more common in the population over 60 years old, and there are differences in critical value situations between male and female patients. Different management strategies are suggested to be adopted for patients of different sexes. And it is necessary to closely monitor the changes of electrocardiogram among patients in the outpatient and neurology departments.
		2024 Vol. 33 (6): 595-600 [Abstract] ( 0 ) [HTML 1KB] [ PDF 1066KB] ( 5 )

	601	Comparative study on perioperative recovery between de novo leadless pacing and transvenous pacing
		WANG Dongxue, LIU Xiaoyu, ZHANG Changying, ZHENG Jie, WANG Ruxing
		Objective To compare perioperative recovery outcomes between de novo leadless pacing and dualchamber transvenous pacing therapies. MethodsA retrospective analysis was performed on clinical data of 12 patients undergoing de novo leadless pacemaker (LPM) implantation and 136 patients undergoing dualchamber transvenous pacemaker (TPM) implantation. By propensity score matching, 11 patients implanted with LPM (LPM group) and 11 patients implanted with dualchamber TPM (TPM group) were selected. The average postoperative hospitalization days and wound recovery of patients were evaluated. Pain visual analogue scale (VAS) and modified Barthel index (MBI) were separately applied to evaluate the degree of pain and functional status of daily living activities in the two groups of patients on postoperative day, postoperative day 1 and 2, and on the day of discharge. ResultsThe average postoperative hospitalization days of the LPM group was shorter than that of the TPM group ［(1.6±0.7) daysvs. (3.1±0.3) days, P<0.01］, while the average wound healing time was also shorter than that of the TPM group ［(1.1±0.3) daysvs. (2.6±0.8) days, P<0.01］. The pain VAS scores of the LPM group were lower than those of the TPM group on postoperative day ［(1.5±0.7) pointsvs. (45±0.8) points, P<0.01］, postoperative day 1 ［(0.5±0.5) pointsvs. (4.0±0.6) points, P<0.01］, postoperative day 2 ［0vs. (2.4±0.5) points, P<0.01］, and on the day of discharge ［0vs. (0.5±0.5) points, P=0.005］. The MBI values of the LPM group were all higher than those of the TPM group on postoperative day 1 ［(75.6±5.3) pointsvs. (53.6±2.3) points, P<0.01］, postoperative day 2 ［(93.6±6.4) pointsvs. (55.6±2.3) points, P<0.01］, and on the day of discharge ［(95.5±5.8) pointsvs. (89.9±4.7) points, P=0.024］. Conclusion De novo LPM therapy proves to be superior to dualchamber TPM therapy with clinical advantages in rapid perioperative recovery of patients.
		2024 Vol. 33 (6): 601-605 [Abstract] ( 0 ) [HTML 1KB] [ PDF 1104KB] ( 5 )

	606	Application value of transesophageal electrophysiologic study in diagnosis and treatment of paroxysmal supraventricular tachycardia
		YANG Yanqiu, WANG Xinkang
		Objective To explore the application value of transesophageal electrophysiologic study (TEEPS) in the diagnosis and treatment of patients with paroxysmal supraventricular tachycardia (PSVT). Methods We retrospectively analyzed the electrophysiological data of 371 patients who had been suspected with PSVT due to palpitation and had undergone TEEPS. The detection of tachycardia by using TEEPS was analyzed. The sensitivity, specificity and accuracy rate of TEEPS in contrast to intracardiac electrophysiologic study (IEPS) were statistically calculated. Results There were 45.55% (169/371) of the patients diagnosed with tachycardia by TEEPS, and 81.07% (137/169) of them were diagnosed with atrioventricular node reentrant tachycardia (AVNRT) and atrioventricular reentrant tachycardia (AVRT). Exercise combined with S1S1 and S1S2 stimulations can significantly increase the detection rate of PSVT. With IEPS as the diagnostic gold standard, the diagnostic accuracy rate of TEEPS for PSVT was 95.54% (107/112). The sensitivity and specificity of TEEPS for AVNRT was 100% and 92.31%, respectively; the sensitivity and specificity of TEEPS for AVRT was separately 93.18% and 98.53%; the sensitivity and specificity of TEEPS for atrial tachycardia was separately 71.43% and 100%. Conclusion TEEPS proves to be safe and effective, which could increase the diagnostic rate of PSVT, and has relatively high diagnostic sensitivity and specificity for a variety of arrhythmias.
		2024 Vol. 33 (6): 606-609 [Abstract] ( 0 ) [HTML 1KB] [ PDF 1017KB] ( 3 )

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		2024 Vol. 33 (6): 610-612 [Abstract] ( 0 ) [HTML 1KB] [ PDF 2289KB] ( 4 )

	613	Effect of deacetylated pilocarpin injection combined with metoprolol on cardiac function and levels of serum cytokines in patients with heart failure
		BAN Fang, MA Xingfang, LIU Fangfei
		Objective To study the effect of deacetylated pilocarpine injection combined with metoprolol on cardiac function and the levels of serum cytokines in patients with heart failure (HF). Methods Seventy patients with HF were retrospectively selected as research objects, and divided into control group and combined medication group according to different treatment schemes, with 35 cases in each group. The control group was treated with metoprolol sustainedrelease tablets, while the combined medication group adopted the medication of deacetylated pilocarpine injection combined with metoprolol sustainedrelease tablets. The clinical efficacy and incidence of adverse reactions were compared between the two groups; the levels of cardiac function indexes ［stroke volume, cardiac index and LVEF)］, hemodynamic parameters ［enddiastolic flow velocity (EDFV), peak systolic flow velocity (PSFV), pulse oximetry (SpO2) and central venous pressure］, and serum cytokines ［(NT-proBNP, CK-MB, angiopoietinlike protein 2 (ANGPTL2) and ANGPTL7］ of the two groups were compared before and after treatment. ResultsThe total effective rate, and the levels of stroke volume, cardiac index, LVEF, EDFV, PSFV and SpO2 in the combined medication group were significantly higher than those in the control group, while the levels of serum NT-proBNP, CK-MB, ANGPTL2, ANGPTL7 and central venous pressure were all significantly lower (all P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion In the treatment of HF, deacetylated pilocarpine injection combined with metoprolol sustainedrelease tablets could relieve the body inflammatory reaction, reduce the degree of myocardial injury, and improve cardiac function, with fewer side effects.
		2024 Vol. 33 (6): 613-616 [Abstract] ( 0 ) [HTML 1KB] [ PDF 1046KB] ( 4 )

	617	Changes of serum 8-OHdG, NT-proBNP and MnSOD levels in patients with heart failure, and their correlation with cognitive function
		JIN Huimin, LI Fangchao, DONG Hongtao
		Objective To investigate the changes of serum 8-hydroxy-2′-deoxyguanosine (8-OHdG), NT-proBNP and manganese superoxide dismutase (MnSOD) in patients with heart failure (HF), and their correlation with cognitive function. MethodsNinetysix patients with HF were prospectively selected as reserach objects (HF group), meanwhile, another 96 healthy physical examinees were also enrolled as the control group. The cognitive function of the HF patients was assessed by the Montreal cognitive assessment (MoCA) score. The serum levels of 8-OHdG, NT-proBNP and MnSOD were compared between the two groups, and patients with different cognitive status at admission. The correlation between the levels of the above three serum markers and MoCA score was also analyzed. The diagnostic value of the above three serum indicators for cognitive dysfunction at admission was analyzed. ResultsThe levels of serum 8-OHdG and NT-proBNP in patients with HF at admission were significantly higher than those in the control group, while the level of serum MnSOD was significantly lower (all P<0.01). The levels of serum 8-OHdG and NT-proBNP in HF patients with cognitive dysfunction were significantly higher than those in HF patients with normal cognition funtion, while the level of serum MnSOD was significantly lower (all P<0.01). For the HF patients at admission, the levels of serum 8-OHdG and NT-proBNP were both positively correlated with the MoCA score, while the level of serum MnSOD was negatively correlated with the MoCA score (all P<0.05). In the diagnosis of cognitive dysfunction among HF patients, the area under the curve, sensitivity, and specificity of the combination of serum 8-OHdG, NT-proBNP, and MnSOD levels at admission were all significantly higher than those by using any single of the three indicators. Conclusion The serum levels of 8-OHdG, NT-proBNP and MnSOD are closely related to complicated cognitive dysfunction in patients with HF. The joint detection of the three markers significantly increases the diagnostic value of cognitive dysfunction in HF patients, which could provide references for clinical treatment.
		2024 Vol. 33 (6): 617-620 [Abstract] ( 0 ) [HTML 1KB] [ PDF 1021KB] ( 3 )

	621	Application value of ambulatory electrocardiographic parameters in diagnosing ventricular arrhythmia of patients with acute myocardial infarction
		WEN Guifeng
		Objective To explore the application value of 24hour ambulatory electrocardiographic parameters in the clinical diagnosis of ventricular arrhythmia in patients with acute myocardial infarction (AMI). Methods A total of 200 AMI patients were performed by ambulatory electrocardiography (AECG) examination, and related parameters were recorded. According to the presence or absence of ventricular arrhythmia, the enrolled patients were divided into ventricular arrhythmia group and nonventricular arrhythmia group. The 24-hour AECG parameters of rMSSD, SDNN, SDANN-index and QT interval variability (QTV) were compared between the two groups. Logistic regression analysis was used to explore the relationship between 24-hour AECG parameters and ventricular arrhythmia occurred in AMI patients; ROC curve analysis was utilized to investigate the efficiency of these parameters in the diagnosis of ventricular arrhythmia among AMI patients. ResultsAmong the 200 AMI patients, 76 cases developed ventricular arrhythmia, with an incidence rate of 38.0%. The indexes of rMSSD, SDNN, SDANNindex and QTV of the AMI patients in the ventricular arrhythmia group were all significantly lower than those in the nonventricular arrhythmia group (all P＜0.05). Logistic regression analysis results showed that rMSSD, SDNN, SDANN-index and QTV were all related to the occurrence of ventricular arrhythmia among AMI patients (all P＜0.05). ROC curve analysis revealed that the AUC values of rMSSD, SDNN, SDANN-index and QTV in the diagnosis of ventricular arrhythmia among AMI patients were 0.907, 0.761, 0.819 and 0.906, respectively, with a certain predictive value. Conclusion The 24-hour AECG parameters of rMSSD, SDNN, SDANN-index and QTV have application values in the clinical diagnosis of ventricular arrhythmia among AMI patients.
		2024 Vol. 33 (6): 621-624 [Abstract] ( 0 ) [HTML 1KB] [ PDF 1441KB] ( 4 )

	625	Effect of coenzyme Ⅰ combined with lovastatin on cardiac function and levels of serum inflammatory factors in patients with coronary heart disease
		CAO Tingting, YANG Maiguang
		Objective To explore the effect of coenzyme Ⅰ combined with lovastatin on cardiac function and the levels of serum inflammatory factors in patients with coronary heart disease (CHD). Methods Retrospective analysis was performed on the clinical data of 120 CHD patients. Among them, 60 cases had been treated with lovastatin as the lovastatin group (lovastatin group), while another 60 cases were given lovastatin + coenzyme Ⅰ for injection as the combined medication group. The clinical efficacy and adverse reaction incidences between the two groups were compared, as well as the cardiac function (wall motion score index and LVEF), and serum inflammatory factors (high-sensitivity C-reactive protein, nuclear factor Kappa B), tumor necrosis factor-α and interleukin-1) and blood lipid (LDL-C, triglyceride, HDL-C and total cholesterol) levels before and after treatment. Results The total clinical effective rate of the combined medication group was statistically higher than that of the lovastatin group (90.00% vs. 75.00%; χ²＝4.675, P＜0.05). The improvement of cardiac function, and serum inflammatory factors and blood lipid levels in the combined medication group was also better than that in the lovastatin group (all P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (16.67% vs. 6.67%; χ²＝2.911, P>0.05). Conclusion In the treatment of CHD, the combination of coenzyme Ⅰ for injection and lovastatin significantly improves cardiac function and the regulation of blood lipid level. Its efficacy is better than that of lovastatin alone with high safety.
		2024 Vol. 33 (6): 625-628 [Abstract] ( 0 ) [HTML 1KB] [ PDF 1051KB] ( 7 )

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		2024 Vol. 33 (6): 629-632 [Abstract] ( 0 ) [HTML 1KB] [ PDF 9969KB] ( 5 )

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		2024 Vol. 33 (6): 633-636 [Abstract] ( 0 ) [HTML 1KB] [ PDF 9316KB] ( 3 )

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		2024 Vol. 33 (6): 640-642 [Abstract] ( 0 ) [HTML 1KB] [ PDF 7897KB] ( 4 )

	643	Research progress of relationship between epicardial adipose tissue and atrial fibrillation
		ABUDURUSULI Subinuer, YASEN Alimire, YAO Juan
		Epicardial adipose tissue (EAT) as an active endocrine tissue located on the surface of the heart, not only provides energy for the heart, but also participates in inflammatory responses and metabolic regulation. Increased amount of epicardial adipose is significantly associated with the increased incidence of atrial fibrillation (AF), potentially promoting the occurrence and persistence of AF through mechanisms such as enhancing local cardiac inflammation, increasing oxidative stress, or directly affecting the electrophysiological properties of cardiomyocytes. This paper reviews the current research status on the relationship between EAT and AF, explores their association mechanism, and proposes future research directions regarding the role of EAT in AF pathogenesis.
		2024 Vol. 33 (6): 643-648 [Abstract] ( 0 ) [HTML 1KB] [ PDF 1096KB] ( 4 )

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		2024 Vol. 33 (6): 644-644 [Abstract] ( 0 ) [HTML 1KB] [ PDF 880KB] ( 5 )

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