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| Effect of deacetylated pilocarpin injection combined with metoprolol on cardiac function and levels of serum cytokines in patients with heart failure |
| BAN Fang, MA Xingfang, LIU Fangfei |
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Abstract Objective To study the effect of deacetylated pilocarpine injection combined with metoprolol on cardiac function and the levels of serum cytokines in patients with heart failure (HF). Methods Seventy patients with HF were retrospectively selected as research objects, and divided into control group and combined medication group according to different treatment schemes, with 35 cases in each group. The control group was treated with metoprolol sustainedrelease tablets, while the combined medication group adopted the medication of deacetylated pilocarpine injection combined with metoprolol sustainedrelease tablets. The clinical efficacy and incidence of adverse reactions were compared between the two groups; the levels of cardiac function indexes ［stroke volume, cardiac index and LVEF)］, hemodynamic parameters ［enddiastolic flow velocity (EDFV), peak systolic flow velocity (PSFV), pulse oximetry (SpO2) and central venous pressure］, and serum cytokines ［(NT-proBNP, CK-MB, angiopoietinlike protein 2 (ANGPTL2) and ANGPTL7］ of the two groups were compared before and after treatment. ResultsThe total effective rate, and the levels of stroke volume, cardiac index, LVEF, EDFV, PSFV and SpO2 in the combined medication group were significantly higher than those in the control group, while the levels of serum NT-proBNP, CK-MB, ANGPTL2, ANGPTL7 and central venous pressure were all significantly lower (all P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion In the treatment of HF, deacetylated pilocarpine injection combined with metoprolol sustainedrelease tablets could relieve the body inflammatory reaction, reduce the degree of myocardial injury, and improve cardiac function, with fewer side effects.
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