Objective  To investigate the predictive value of systemic immune-inflammation index (SII) for the occurrence of ventricular arrhythmia (VA) after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI). Methods  A total of 100 AMI patients undergoing emergency PCI were consecutively enrolled, and divided into a VA group (n=52) and a non-VA group (n=48) based on the occurrence of VA within 7 days after PCI. Clinical baseline data and laboratory test results were collected. Complete blood count parameters included white blood cell, neutrophil, lymphocyte, and platelet counts, which were used to calculate SII, neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR). Cardiac ultrasound was performed to assess left ventricular end-diastolic diameter (LVEDD), left ventricular end-diastolic volume (LVEDV), and LVEF. Logistic regression analysis was used to identify factors influencing VA occurrence within 7 days after PCI. The predictive performance was evaluated using ROC curve analysis, and the dose-response relationship was assessed with restricted cubic spline (RCS) plots. Results  The VA group had significantly higher levels of SII, PLR, NLR, LVEDD and LVEDV, and significantly lower LVEF compared to the non-VA group (all P<0.05). Multivariate Logistic regression analysis indicated that SII was an independent risk factor for VA within 7 days after PCI in AMI patients (OR=1.01, P<0.01). RCS plot analysis revealed a non-linear positive correlation between SII and the risk of VA (P=0.002). ROC curve analysis showed that the optimal cut-off value of SII for predicting VA was 973×109/L, with a sensitivity of 81% and a specificity of 71%. Conclusion  SII>973×109/L could serve as a potential predictor for VA after PCI in AMI patients, providing valuable insight for early identification of high-risk patients and guiding clinical intervention.

Objective  To evaluate the clinical utility of ST-segment duration and ST/QT ratio in differentiating between hypertrophic cardiomyopathy (HCM) and hypertensive ventricular hypertrophy (HVH). Methods  A total of 98 subjects were enrolled, including 45 patients without cardiac disease (control group), 22 patients with HCM (HCM group), and 31 patients with HVH (HVH group). All participants underwent electrocardiogram (ECG) examinations. The ST-segment duration, QT interval, and ST/QT ratio were compared among the groups, while the diagnostic sensitivity and specificity of ST-segment duration and ST/QT for distinguishing HCM from HVH were assessed. Results  Statistically significant differences were observed in ST-segment duration and ST/QT among the three groups (both P<0.01). Compared with the control group, both HCM and HVH groups exhibited significantly elevated ST-segment duration and ST/QT ratio (both P<0.01), while no statistically significant difference was found in the QT interval. Diagnostic efficiency evaluation revealed that the sensitivity of ST-segment duration and ST/QT for diagnosing HCM was 77.27% and 86.36%, respectively, with specificity of 86.67% and 77.78%, and AUC values of 0.847 (P<0.01) and 0.859 (P<0.01). For diagnosing HVH, the sensitivity of ST-segment duration and ST/QT was 64.52% and 70.97%, respectively, with specificity of 97.78% and 93.33%, and AUC values of 0.833 (P<0.01) and 0.849 (P<0.01), respectively. Conclusion  Both ST-segment duration and ST/QT could serve as diagnostic indicators for HCM and HVH, with high specificity.

Objective  To systematically analyze the clinical characteristics of septic patients complicated by myocardial infarction (MI), evaluate its impact on in-hospital mortality, and to explore related influencing factors and prognostic indicators. Methods  Based on the MIMIC-Ⅳ v2.0 database, a total of 12 838 adult septic patients meeting the Sepsis-3 diagnostic criteria were included. They were divided into two groups according to the presence of MI: a sepsis with MI group (n=2 236) and a sepsis-alone group (n=10 602). Demographic data, clinical indicators, and outcomes were compared between the two groups. Multivariate Logistic regression and random forest models were used to identify key predictors of in-hospital mortality, and subgroup stratification analysis was performed. Results  Septic patients with MI were older, had a higher proportion of males, a significantly higher prevalence of diabetes and chronic obstructive pulmonary disease (COPD), and higher APACHE-Ⅲ and SAPS-Ⅱ scores than those in the sepsis-alone group (all P<0.05). The in-hospital mortality rate in the sepsis with MI group was 25.2%, significantly higher than that in the sepsis-alone group (19.9%, P<0.001). Multivariate Logistic regression analysis showed that MI was an independent risk factor of in-hospital mortality (OR=1.26, 95% CI 1.11-1.43). Subgroup analysis revealed that in patients with MI, COPD, hypoalbuminemia, and low platelet count were significantly associated with an increased risk of death, while diabetes showed a protective effect in patients without MI. The random forest model further validated the importance of these variables in predicting mortality risk. Additionally, statin use was associated with reduced 90-day mortality in septic patients with MI. Conclusion  MI significantly aggravates the condition of septic patients and increases the risk of in-hospital mortality, highlighting the importance of early risk stratification and intervention. Predictive models combining multivariate statistics and machine learning may facilitate more accurate individualized prognostic assessment.

Objective  To evaluate the safety and efficacy of the Medtronic second-generation cryoballoon ablation (CBA) in treating non-valvular paroxysmal atrial fibrillation (PAF). Methods  Sixty-five patients with non-valvular PAF who had not previously undergone pulmonary vein isolation (PVI) were enrolled. All patients were treated by using the Medtronic second-generation cryoballoon ablation system. Baseline data, procedure-related parameters, and 12-month follow-up results were collected. Based on whether atrial fibrillation recurred, these patients were divided into a non-recurrence group and a recurrence group. General clinical data, immediate procedural success rate, intraoperative parameters, and procedure-related complications were compared between the two groups. Results  All 65 patients successfully achieved circumferential PVI solely through CBA, with an immediate procedural success rate of 100%. The atrial fibrillation ablation success rate at 12-month follow-up was 908%. The mean procedure time was (98.68±19.13) min. The overall incidence of intraoperative and postoperative complications was 7.7%, with phrenic nerve injury occurring in 3.1% of cases. Conclusion  Second-generation CBA demonstrates high safety and efficacy in treating nonvalvular PAF, supporting its clinical utility for tailored therapeutic strategies.

Objective  To investigate the risk factors for new-onset atrial fibrillation (AF) in patients with septic shock, and their impact on prognosis. Methods  A total of 302 patients with septic shock were retrospectively enrolled, and divided into an AF group and a control group based on the occurrence of new-onset AF. Baseline characteristics were compared between the two groups. Univariate and multivariate Logistic regression analyses were used to identify independent risk factors for new-onset AF. Propensity score matching (PSM) analysis was employed to assess the impact of new-onset AF on the prognosis of patients. Results  During hospitalization, 57 patients developed new-onset AF. Compared with the control group, patients in the AF group were older, with a larger left atrial diameter, and lower left ventricular ejection fraction. Multivariate Logistic regression analysis identified age, left atrial diameter, and electrolyte disturbances as independent risk factors for new-onset AF in patients with septic shock. PSM analysis revealed that patients in the AF group had significantly prolonged ICU length of stay, although there was no statistically significant difference in in-hospital mortality between the two groups. Conclusion  The incidence of new-onset AF is high in patients with septic shock, and it significantly prolongs ICU length of stay. Age, enlargement of left atrial diameter, and electrolyte disturbances serve as independent risk factors for new-onset AF, providing a basis for early risk stratification and targeted intervention.

Objective  To evaluate the short-term efficacy of proximal gastrectomy combined with tubular gastroesophageal circular anastomosis in the treatment of earlystage esophagogastric junction adenocarcinoma (EGJA). Methods  Clinical data of 7 patients with early-stage EGJA who had undergone this procedure were retrospectively analyzed. Parameters included baseline characteristics, perioperative indicators, and follow-up outcomes, with a focus on perioperative status, complication incidence, postoperative nutritional status and gastroesophageal reflux. Results  All the 7 patients successfully underwent laparoscopy-assisted proximal gastrectomy with tubular gastroesophageal circular anastomosis. The mean operative time was (227.1±51.9) minutes, the mean anastomosis time was (54.4±10.0) minutes, and the mean intraoperative blood loss was (47.1±28.7) mL. The mean time to first flatus was (3.3±1.3) days, while the mean hospital stay was (21.1±7.6) days. After the procedure, one patient developed an anastomotic leak, with no other complications recorded. At the 6-month follow-up, the mean serum albumin level was (39.2±3.4) g/L, the mean hemoglobin level was (124.6±13.8) g/L, and the mean gastroesophageal reflux disease questionnaire score was (3.1±0.9) points. Both gastroscopy and upper gastrointestinal radiography with iodinated contrast studies showed no significant signs of reflux esophagitis. Conclusion  Laparoscopic proximal gastrectomy with tubular gastroesophageal circular anastomosis is a safe and feasible approach for patients with early-stage EGJA. Initial findings suggest that this technique demonstrates reliable anti-reflux efficacy, helps to reduce the risk of postoperative reflux esophagitis, and contributes to improved quality of life after surgery.

Objective  To investigate the difference in the expression of forkhead box Q1 (FOXQ1) and epithelial-cadherin (E-cadherin) proteins in gastric cancer tissues and adjacent tissues, analyze their relationship with clinicopathological features, and evaluate their potential clinical effect in the development and progression of gastric cancer. Methods  The protein expression levels of FOXQ1 and E-cadherin were detected in 50 cases of gastric cancer tissues and matched adjacent tissues using the EnVision immunohistochemical method. The correlations between their expression and clinicopathological parameters were analyzed, and the relationship between their expression levels in gastric cancer tissues was further assessed. Results  Both FOXQ1 and E-cadherin were expressed in gastric cancer and adjacent tissues. FOXQ1 protein was primarily localized in the cytoplasm, while E-cadherin protein was mainly expressed on the cell membrane. The positive expression rate of FOXQ1 was significantly higher in gastric cancer tissues than that in adjacent tissues (P<0.05), and its expression was associated with lymph node metastasis and TNM stage (both P<0.05). In contrast, the positive expression rate of E-cadherin was significantly lower in gastric cancer tissues than that in adjacent tissues (P<0.01), and its expression correlated with the degree of tumor differentiation, depth of invasion, lymph node metastasis and TNM stage (all P<0.05). A negative correlation was observed between FOXQ1 and E-cadherin expression in gastric cancer tissues (r=－0.301,P＜0.05). Conclusion  The expression of both FOXQ1 and E-cadherin is closely associated with lymph node metastasis and TNM stage in gastric cancer. They may jointly participate in the invasion and metastasis processes of gastric cancer, suggesting their potential as therapeutic targets for advanced gastric cancer.

Objective  To investigate the risk factors associated with calcific aortic valve disease (CAVD), and to provide a basis for clinical guidance and intervention. Methods  A retrospective analysis was conducted on 184 patients diagnosed with CAVD by echocardiography. Clinical data and information on comorbidities were collected, and 217 subjects with normal aortic valve morphology were selected as a control group. Multivariate Logistic regression analysis was used to identify independent risk factors and related predisposing factors for CAVD. Results  Advanced age, coronary heart disease, heart failure, renal insufficiency, or cerebral infarction were associated with a higher risk of CAVD. Among these, advanced age and renal insufficiency were independent risk factors for CAVD. Analysis of laboratory indicators suggested that lipoprotein(a) may be an independent risk factor for CAVD, and monitoring this indicator could help identify high-risk populations. ConclusionThe occurrence of CAVD is closely related to advanced age and renal insufficiency, and elevated lipoprotein(a) may also be involved in its pathogenesis.

Objective  To investigate the ambulatory electrocardiography (AECG) characteristics of coronary slow flow (CSF) phenomenon, and analyze its related influencing factors. Methods  The clinical data of 108 patients with suspected coronary heart disease (CHD) who had undergone coronary angiography were retrospectively analyzed. According to the TIMI flow grade, patients were divided into a slow flow group (grade≤2, n=58) and a normal flow group (grade 3, n=50). All patients underwent 24-hour AECG monitoring to analyze the AECG characteristics of CSF and related influencing factors. Results  There were no statistically significant differences between the two groups in age, hypertension, diabetes, history of alcohol consumption, or the use of dual antiplatelet agents, lipid-lowering drugs, ACEI/ARB, calcium channel blockers, beta-blockers or isosorbide mononitrate (all P>0.05). The proportions of males, smokers, and hyperuricemia were significantly higher in the slow flow group than those in the normal flow group (all P<0.05). There were no statistically significant differences in the incidence of paroxysmal atrial tachycardia, paroxysmal ventricular tachycardia, atrial premature beats, premature ventricular contraction, T-wave changes, left or right bundle branch block, or atrioventricular block between the two groups (all P>0.05). No statistically significant differences were observed in pNN50, SDANN or rMSSD (all P>0.05). The maximum heart rate and SDNN were significantly lower in the slow flow group than those in the normal flow group (both P<0.05). There were no statistically significant differences in hemoglobin, total cholesterol, triglycerides, alanine aminotransferase, aspartate aminotransferase, albumin, thrombin time, or D-dimer levels between the two groups (all P>0.05). Hematocrit was significantly higher in the slow flow group than that in the normal flow group (P<0.05). Five factors related to general information, AECG findings, and blood test results that affected the CSF phenomenon were selected for multivariate Logistic regression analysis. It showed that male, smoking history, hyperuricemia, low maximum heart rate, and low SDNN were independent influencing factors for CSF phenomenon. Conclusion  Male sex, smoking history, hyperuricemia, low maximum heart rate, and low SDNN are independent related factors for coronary slow flow phenomenon and hold significant value in predicting CSF in patients with coronary heart disease.

Objective  To investigate the prevalence and influencing factors of electrocardiogram (ECG) abnormalities in patients with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS). Methods  A total of 680 HIV/AIDS patients were enrolled in this study. All patients underwent ECG examination, and the incidence of abnormalities was recorded. Based on the ECG results, patients were categorized into an abnormal group (n=455) and a normal group (n=225). Univariate and multivariate Logistic regression analyses were employed to identify independent risk factors for ECG abnormalities. Results  Among the 680 patients, ECG abnormalities were detected in 455 cases, yielding an abnormality rate of 66.91%. Univariate Logistic regression analysis revealed that the two groups showed statistically significant differences in smoking history, pulmonary infection, CD4⁺ T-cell count, CD8⁺ T-cell count, antiretroviral therapy regimen, and the duration of highly active antiretroviral therapy (HAART) (all P<0.01). Multivariate Logistic regression analysis further confirmed that smoking history, co-existing pulmonary infection, CD4⁺ T-cell count < 200 cells/μL, CD8⁺ T-cell count < 500 cells/μL, receiving HAART, and a HAART duration of ≥2 years were independent risk factors for ECG abnormalities. Conclusion  The incidence of ECG abnormalities is high among HIV/AIDS patients, and is influenced by various factors, including immune status, co-infections and treatment-related factors. Clinically, it is essential to urge patients to quit smoking strictly, actively manage inflammatory conditions (such as pulmonary infection), initiate standardized antiretroviral therapy as early as possible, and strengthen regular ECG monitoring to improve their prognosis.

Objective  To investigate the impact of left atrial sphericity (LASP) and functional mitral regurgitation on the maintenance of sinus rhythm after radiofrequency catheter ablation (RFCA) in patients with atrial fibrillation (AF), and to evaluate their correlation with procedural outcomes. Methods  A total of 105 patients undergoing initial RFCA treatment for AF were enrolled, and categorized into a non-recurrence group (66 cases) and a recurrence group (39 cases) based on post-operative follow-up results. General clinical data, and echocardiographic and left atrial CT angiography related parameters ［including left atrial anteroposterior diameter, LVEF, mitral regurgitation area (MRA), left atrial volume, LASP, etc.］ were collected, and made intergroup comparisons. Univariate and multivariate Cox regression analyses were used to identify factors associated with AF recurrence. Results  The left atrial anteroposterior diameter, mitral regurgitation rate, MRA, left atrial volume, and LASP were all significantly higher in the recurrence group compared to the non-recurrence group (all P＜0.05). Cox regression analysis indicated that LASP, mitral regurgitation, and MRA were significantly associated with post-operative recurrence (all P＜0.05). Conclusion  LASP and mitral regurgitation are closely associated with AF recurrence after RFCA, and could serve as reference indicators for predicting post-operative recurrence.

Objective  To investigate the predictive value of fragmented QRS complex (fQRS) for the occurrence of major adverse cardiovascular events (MACEs) within 6 months after percutaneous coronary intervention (PCI) in patients with coronary heart disease. Methods  A total of 96 patients with coronary heart disease who had undergone PCI were retrospectively enrolled. They were followed up for 6 months postoperatively, and divided into a MACEs group (24 cases) and a non-MACEs group (72 cases) based on the occurrence of MACEs. Clinical baseline data and electrocardiogram results on admission were collected, and the difference in the positive rate of fQRS between the two groups was compared. Multivariate Logistic regression analysis was used to explore independent risk factors for MACEs occurring shortly after PCI, while the predictive performance of each factor for MACEs was evaluated using ROC curves. Results  During the follow-up, the incidence of MACEs was 25.00% (24/96). The levels of LDL-C, total cholesterol, and the positive rate of fQRS in the MACEs group were all significantly higher than those in the non-MACEs group, while LVEF was lower than that in the non-MACEs group (all P<0.05). Multivariate Logistic regression analysis showed that LDL-C, total cholesterol, LVEF, and fQRS were all independent risk factors for MACEs occurring shortly after PCI (all P<0.05). ROC curve analysis indicated that the AUC value of fQRS for predicting MACEs was 0.813 (95%CI 0.710-0.915), with a sensitivity and specificity of 83.33% and 79.17%, respectively. Its predictive value was higher than that of LDL-C, total cholesterol, and LVEF. Conclusion  The index of fQRS is an independent predictive factor for MACEs within 6 months after PCI in patients with coronary heart disease, and has certain predictive value.

Objective  To explore the relationship between parameters of multifrequency bioelectrical impedance and cardiovascular events in maintenance hemodialysis (MHD) patients. Methods  A total of 126 MHD patients were selected as study subjects, and divided into a cardiovascular event group (36 cases) and a control group (90 cases) based on the occurrence of cardiovascular events during hemodialysis. Both groups underwent multifrequency bioelectrical impedance testing; we obtained relevant parameters ［phase angle, extracellular water/intracellular water (ECW/ICW), lean tissue index (LTI), and over-hydration (OH)］. Baseline data, laboratory indicators, and multifrequency bioelectrical impedance parameters were compared between the two groups. Point-biserial correlation analysis was used to explore the relationship between multifrequency bioelectrical impedance parameters and cardiovascular events in MHD patients. ROC curve analysis was employed to evaluate the predictive value of these parameters for the risk of cardiovascular events. Results  Among the 126 patients, there were 16 cases of coronary heart disease, 12 cases of heart failure, and 8 cases of arrhythmia, resulting in a cardiovascular event incidence of 28.57% (36/126). The proportion of patients with inadequate hemodialysis, ECW/ICW, and OH values were all significantly higher in the cardiovascular event group compared to the control group (all P<0.01), while phase angle and LTI values were significantly lower (all P<0.01). Point-biserial correlation analysis revealed that the incidence of cardiovascular events in MHD patients was negatively correlated with phase angle and LTI, and positively correlated with ECW/ICW and OH (all P<0.01). ROC curve analysis showed that the AUC value for phase angle, ECW/ICW, LTI, OH individually and in combination for predicting the risk of cardiovascular events in MHD patients were 0.853, 0.878, 0.866, 0.856, and 0.944, respectively, indicating good predictive value. Conclusion  Various parameters of multifrequency bioelectrical impedance are closely related to the occurrence of cardiovascular events in MHD patients, and thus have certain predictive value for such events.

Objective  To investigate the predictive value of the ratio of the posterior horn width of the lateral ventricle to biparietal diameter (BPD), and lateral ventricle width (LVW) measured by prenatal color Doppler ultrasound (CDUS) on early neurodevelopmental outcomes in neonates. Methods  A retrospective analysis was conducted on 132 pregnant women admitted to our hospital. Based on the early neurodevelopmental outcomes of their neonates, the subjects were divided into a normal group (n=105) and an abnormal group (n=27). General data and examination results were collected. Variables that showed statistically significant differences in the Logistic regression analysis were selected to plot the ROC curve so as to evaluate the predictive efficiency of the ratio of the posterior horn width of the lateral ventricle to BPD and LVW measured via prenatal CDUS for early neurodevelopmental outcomes in neonates. Results  The ratio of the posterior horn width of the lateral ventricle to BPD, and LVW were both significantly higher in the abnormal group than those in the normal group (t=2.984, 5.706), with statistically significant differences (both P<0.05). ROC curve analysis showed that the AUC values for predicting early neurodevelopmental outcomes using the ratio and LVW alone were 0.701 and 0.799, respectively, while the combined prediction yielded an AUC value of 0.836, demonstrating high sensitivity and specificity. It indicated that the combined index had greater predictive value for early neurodevelopmental outcomes in neonates. Conclusion  The ratio of the posterior horn width of the lateral ventricle to BPD, and LVW, as detected by prenatal CDUS, have significant predictive value for early neurodevelopmental outcomes in neonates.

Objective  To investigate the effect of high-pressure non-invasive positive pressure ventilation (NIPPV) on the oxygenation index in stroke patients complicating respiratory failure. Methods  Eighty stroke patients with respiratory failure were selected, and randomly divided into a high-pressure ventilation group and a low-pressure ventilation group using a random number table method, with 40 patients in each group. The inspiratory pressure of the ventilator was set at 20-24 cm H₂O in the high-pressure ventilation group and 12-16 cm H₂O in the low-pressure ventilation group. Treatment efficacy, blood gas parameters, pulmonary function indicators, length of hospital stay, and incidence of adverse reactions were compared between the two groups. Results  There was no statistically significant difference in the total effective rate between the two groups (P>0.05). The oxygenation index and arterial partial pressure of oxygen were both significantly higher in the high-pressure ventilation group than those in the low-pressure ventilation group, while the arterial partial pressure of carbon dioxide, heart rate, and respiratory rate were all significantly lower (all P<0.05). The forced expiratory volume in the first second, forced vital capacity, and the ratio of forced expiratory volume in the first second to forced vital capacity were all significantly higher in the high-pressure ventilation group than those in the low-pressure ventilation group (all P<0.05). The length of hospital stay was significantly shorter in the high-pressure ventilation group than that in the lowpressure ventilation group (P<0.05). However, there were no statistically significant differences in the incidence of gastrointestinal distension or mask-related skin injury between the two groups (P>0.05). Conclusion  High-pressure NIPPV shows similar overall therapeutic efficacy to low-pressure NIPPV in stroke patients with respiratory failure, however, it could significantly improve oxygenation index and other blood gas parameters, enhance pulmonary function, shorten the length of hospital stay, and would not increase the incidence of adverse reactions.

Objective  To compare the clinical efficacy of ultrasonic osteotomy versus conventional chisel osteotomy and crown splitting for the extraction of mandibular low-level impacted wisdom teeth. Methods  A retrospective study was conducted on the clinical data of 128 patients with mandibular low-level impacted wisdom teeth. Based on surgical methods, they were divided into an ultrasonic osteotomy group (n=66) and a control group (n=62, receiving conventional chisel osteotomy and crown splitting). Perioperative indicators, levels of inflammatory factors ［peroxisome proliferator-activated receptor γ (PPARγ), pentraxin 3 (PTX3) and interleukin-6 (IL-6)］, the degree of mouth opening limitation before and after surgery, quality of life scores, and the incidence of complications were compared between the two groups. Results  The integrity of the extraction socket was better in the ultrasonic osteotomy group than that in the control group, with less intraoperative bleeding and shorter operative time (all P<0.01). On postoperative day 3, the serum levels of PPARγ, PTX3, and IL-6 in the ultrasonic osteotomy group were all lower than those in the control group (all P<0.01). Postoperatively, the degree of mouth opening limitation was milder in the ultrasonic osteotomy group compared to the control group (P<0.01). At 2 and 4 weeks after operation, the quality of life scores were lower in the ultrasonic osteotomy group than those in the control group (both P<0.01). The difference in the incidence of complications between the two groups (4.55% vs. 14.51%) was not statistically significant (P>0.05). Conclusion  Using the ultrasonic osteotomy technique for extracting mandibular low-level impacted wisdom teeth helps to preserve the integrity of the extraction socket, alleviate postoperative mouth opening limitation, reduce the inflammatory response, and improve patients' postoperative quality of life.

Objective  To explore the application effect of positive rumination thinking nursing intervention in patients after liver cancer interventional surgery. Methods  A total of 101 patients after liver cancer interventional surgery were selected as research subjects, and divided into a control group (51 cases, receiving routine nursing intervention) and an observation group (50 cases, receiving positive rumination thinking nursing intervention) according to the nursing plan. The rehabilitation process, coping styles ［simplified coping style questionnaire (SCSQ)］, uncertainty in illness ［Chinese version of Mishel's uncertainty in illness scale for adults (MUIS-A)］, and negative emotions ［Beck anxiety inventory (BAI) and Beck depression inventory (BDI)］ were compared between the two groups. Results  Compared with the control group, after the intervention, the observation group had significantly shorter duration of hospitalization, and significantly earlier time of the first bed-to-chair transfer, first defecation time and first exhaust time (all P<0.01). Compared with the control group, after the intervention, the observation group had higher scores in the positive coping dimension of SCSQ and lower scores in the negative coping dimension (both P<0.01). Compared with the control group, after the intervention, the observation group had lower scores in all dimensions of MUIS-A, and BAI and BDI scores (all P<0.01). Conclusion  Positive rumination thinking nursing intervention could effectively reduce negative emotions, alleviate uncertainty in illness, promote positive coping behaviors, and accelerate the postoperative rehabilitation process in patients after liver cancer interventional surgery.

Objective  To explore the effect of family-centered continuing education and follow-up on the nutritional status of children with Hirschsprung's disease (HD) and the disease management ability of their primary caregivers. Methods  Eighty-four children with HD were randomly divided into a control group (n=42) and an observation group (n=42) using a random number table method. The control group received routine care and post-discharge follow-up, while the observation group received additional family-centered continuing education and systematic follow-up. Nutritional indicators ［including prealbumin (PA), albumin and total protein (TP)］, and caregivers' disease management ability ［assessed using the HD knowledge score and the family caregiver task inventory (FCTI) score］ were evaluated and compared between the two groups at discharge and one year after discharge. These patients' defecation function, and quality of life ［assessed using the pediatric quality of life inventory (PedsQL) score］ were also evaluated one year after discharge. Results  One year after discharge, the levels of PA, albumin, and TP in both groups were all significantly higher than those at discharge (all P<0.05), and there were statistically significant differences between the two groups (all P<0.01). The caregivers' HD knowledge scores in both groups were higher than those at discharge, with the observation group being significantly higher than the control group (all P<0.05). The FCTI scores of both groups decreased compared to those at discharge, while the scores of the observation group were significantly lower than those of the control group (all P<0.05). One year after discharge, the clinical defecation function score of the observation group was better than that of the control group, and the PedsQL score was also significantly higher than that of the control group (all P<0.05). Conclusion  Family-centered continuing education and follow-up could effectively increase caregivers' disease knowledge level and caregiving capacity. It improves defecation function and quality of life in children with HD, and has a positive impact on their long-term nutritional status.

Objective  To investigate the intervention effect of specialist health education combined with continuity of care on patients with dry eye syndrome after cataract surgery. Methods  One hundred patients with dry eye syndrome after cataract surgery were randomly divided into an observation group and a control group using a random number table method, with 50 cases in each group. The observation group received a combined intervention model of specialist health education and continuity of care, while the control group received routine nursing care. The improvement in visual acuity (measured by the logMAR chart), tear film stability, self-care ability, and occurrence of complications were compared between the two groups. Results  After the intervention, the observation group showed better visual acuity compared to the control group ［(0.12±0.05) vs. (0.25±0.08), P<0.05］. Furthermore, all tear film stability indicators and self-care ability scores in the observation group were all significantly better than those in the control group, while the incidence of complications was significantly lower; all the differences between the two groups were statistically significant (all P<0.05). Conclusion  The combined nursing model could effectively promote the recovery of patients' visual acuity, enhance tear film stability, improve their selfcare ability, and reduce the incidence of complications.

Cancer-related atrial fibrillation (CR-AF) is a common complication in cancer patients, closely associated with the tumor itself, anti-cancer treatments, and systemic inflammatory responses. With advances in cancer treatment and prolonged survival of patients, the incidence of CR-AF has increased significantly, making it an important research focus in the field of cardio-oncology. Atrial fibrillation is particularly prevalent among patients with lung, breast, or esophageal cancers. CR-AF significantly elevates the risk of stroke, heart failure, and systemic embolism, thereby adversely affecting patients' quality of life and long-term prognosis. The pathogenesis of CR-AF involves multiple mechanisms, including tumor-induced systemic inflammation, oxidative stress, and atrial structural remodeling, while the cardiotoxic effects of chemotherapy and radiotherapy may also promote the occurrence of atrial fibrillation. Although the clinical significance of CR-AF is gaining increasing attention, currently used assessment tools for atrial fibrillation risk such as CHA₂DS₂-VASc and HAS-BLED have limitations in cancer populations. Moreover, anticoagulation therapy faces the challenge of balancing thrombotic and bleeding risks. Future research should focus on precise risk assessment, individualized treatment strategies, and early intervention to improve overall treatment outcomes and quality of life in cancer patients.

Depression is a mental disorder characterized by high prevalence and substantial disease burden. Its pathophysiological process is closely associated with dysfunction of the autonomic nervous system. Heart rate variability (HRV), a non-invasive and quantitative indicator for assessing autonomic nervous function, provides a crucial window into revealing the pathophysiological mechanisms of depression. This article systematically reviews the HRV characteristics in patients with depression, related pathophysiological mechanisms, challenges in practical measurement, and its applications in diagnosis and treatment, aiming to explore the potential value and application prospects of HRV as a biomarker for precision management in depression.

The fragmented QRS complex (fQRS) is an important abnormal manifestation in the electrocardiogram (ECG), and has attracted widespread attention in the field of cardiovascular diseases in recent years. With in-depth research on fQRS, it has been found to be closely associated with coronary heart disease, arrhythmia, hypertension, heart failure, cardiomyopathy and other diseases. It can serve as an important indicator for predicting cardiovascular events and assessing patients' prognosis. This article summarizes the research progress of fQRS in the related fields of cardiovascular diseases, explores its manifestations in the ECG and its clinical significance, so as to provide a reference for the application of fQRS in cardiovascular diseases.

Atrial fibrillation (AF) is a common arrhythmia with a complex pathogenesis. Recent studies have found that autoimmune mechanism plays a significant role in the occurrence, progression, and prognosis of AF. This review summarizes the mechanisms underlying the involvement of autoimmune responses in AF, including the activation of immune cells and the specific roles of autoantibodies during the pathological progression of AF. These findings provide a theoretical foundation for developing novel strategies in the prevention and management of AF.

The Internet-based remote electrocardiogram (ECG) platform centered on Xi'an International Medical Center Hospital has successfully integrated 80 medical institutions, establishing a multi-dimensional remote diagnosis and treatment network that encompasses routine ECG and ambulatory electrocardiography monitoring, and wearable device and dynamic blood pressure monitoring. The project has served over 100 000 patients cumulatively, with an average monthly data processing volume of 5 000 cases. It has effectively promoted the implementation of hierarchical medical treatment system and early warning mechanisms for cardiovascular diseases. Against the background of the deep integration of information technology and healthcare, Internet-based medical services are experiencing rapid development. This paper systematically analyzes the practical value of this model from multiple dimensions, including technical architecture, data management, clinical efficacy, and health economics, aiming to provide valuable insights for the collaborative development of regional healthcare.