Objective  To investigate the potential pathogenesis of Posner-Schlossman syndrome (PSS) by analyzing the inflammatory cytokine profile in the aqueous humor of patients with cytomegalovirus (CMV)-negative PSS complicating systemic lupus erythematosus (SLE). Methods  Two patients (3 eyes) clinically diagnosed with PSS complicated by SLE and negative for CMV-DNA in the aqueous humor were enrolled as a PSS group, while three patients (3 eyes) with primary open-angle glaucoma (POAG) were enrolled as a control group (POAG group). Inflammatory cytokines in the aqueous humor were detected using protein chip analysis, and differentially expressed inflammatory cytokines were subjected to gene ontology (GO) functional enrichment analysis, and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis. Results  Compared with the POAG group, the PSS group showed significantly upregulated the expression of platelet-derived growth factor-BB (PDGF-BB), regulated upon activation normal T cell expressed and secreted (RANTES), and neutrophil-activating peptide-2 (NAP-2). GO functional and KEGG pathway enrichment analyses indicated that these differentially expressed proteins were mainly involved in leukocyte chemotaxis and migration, and were primarily distributed in vesicle lumen and platelet α granules. Conclusion  In CMV-negative PSS patients with SLE, the aqueous humor showed upregulated expression of PDGF-BB, RANTES and NAP-2 levels, suggesting a possible special inflammatory pattern mediated by autoimmunity.

Objective  To investigate the correlation between sleep duration and Gensini score for coronary artery lesions. Methods  A total of 367 patients who were hospitalized in the Department of Cardiology at Fengcheng Hospital of Fengxian District, Shanghai, from October 2023 to February 2025, and underwent coronary angiography (CAG) were enrolled as study subjects. General data, sleep duration, clinical data, and CAG results were collected. Gensini scores were calculated based on CAG results using the Gensini scoring system. According to sleep duration, the study subjects were divided into sleep duration <6 h group (n=64), 6-8 h group (n=196), and >8 h group (n=107). The relationship between sleep duration and Gensini score was analyzed. Results  No statistically significant differences were observed in sex, age, height, body weight, smoking, alcohol consumption, blood pressure, or blood lipids among the three groups. Compared with the sleep duration 6-8 h group, the Gensini scores were significantly higher in the sleep duration <6 h and >8 h groups (both P<0.001). Multivariate Logistic regression analysis showed that compared with the sleep duration 6-8 h group, both of the <6 h and >8 h groups had higher risks of elevated Gensini scores, with OR (95%CI) of 30.183 (10.066-90.505) and 3.784 (2.180-6.568), respectively (both P<0.001). Conclusion  Both too short and too long sleep durations are associated with increased severity of coronary artery lesions, exhibiting a “U-shaped” risk relationship. It suggests that maintaining an appropriate sleep duration (6-8 h) is of great significance for the prevention and management of coronary heart disease.