Objective To analyze the efficacy of metoprolol combined with amiodarone in the treatment of coronary heart disease (CHD) complicating premature ventricular contraction (PVC). Methods A total of 198 patients with CHD complicating PVC were divided into control and observation groups in the random number table method, with 99 cases in each group. The control group was treated with amiodarone while the observation group was treated with amiodarone combined with metoprolol following oral administration. The course of medication was both one month in the two groups. The clinical efficacy, ambulatory electrocardiography (AECG) indexes, heart rate variability (HRV) indexes, cardiac function indicators, and the occurrence of adverse reactions were compared between the two groups. ResultsThe total effective rate of the observation group was significantly higher than that of the control group; QT interval dispersion and corrected QT interval dispersion after treatment were both lower than those in the control group while each HRV index and cardiac function indicator were all better than those in the control group (all P<0.05). there="" was="" no="" adverse="" reaction="" during="" treatment="" in="" both="" groups.="" conclusion="" metoprolol="" plus="" amiodarone="" could="" further="" improve="" hrv="" indexes="" and="" cardiac="" function="" in="" chd="" patients="" complicated="" by="" pvc="" and="" significantly="" promote="" the="" efficacy.="" it="" is="" worthy="" of="" clinical="" promotion="" and="" application.="">