Abstract：Objective By measuring the level of plasma resistin, to study its roles in the occurrence and maintenance of lone atrial fibrillation(LAF), and analyze the related influential factors of plasma resistin level and risk factors of AF. Methods Research objects were 140 patients consulting in the department of cardiology of our hospital because of palpitation from June to December in 2014. The experimental group consisted of AF patients who were classified into patients with LAF(60 cases) and those with AF complicating hypertension(55 cases), respectively. The LAF cases were further divided into paroxysmal AF group and persistent AF group, each with 30 cases. In the control group were normal people(25 cases). The difference of plasma resistin level was analyzed between AF patients and normal people by oneway abalysis of variance, and its related influential factors for AF patients were analyzed in methods of Pearson correlation analysis and multiple linear regression. Logistic regression was applied in analyzing risk factors of AF. Results (i) In terms of high sensitive C reactive protein( hs-CRP) and plasma resistin level, the levels of AF group were all higher than those of control group; among the AF patients, the levels of LAF group were lower than those of AF complicating hypertension group and the levels of paroxysmal AF group were lower than those of persistent AF group. (ii) Pearson correlation analysis showed that plasma resistin level was positively correlated with hs-CRP level(r=0.530, P=0.000), left atrial diameter(r=0.265, P=0.004) and systolic blood pressure(SBP)(r=0.364, P=0.000). Multiple linear regression analysis further revealed that there was a linear relationship among SBP, hs-CRP and plasma vesistin levels: Y=-2.172+0.089 SBP+1.347 hs-CRP(R2=0.307, P<0.05). (iii) Logistic regression analysis indicated that plasma resistin and hs-CRP levels were both enrolled into the regression equation, with OR>1. Conclusion (i) The level of plasma resistin in LAF group was significantly higher than that in control group, especially the cases in persistent AF group, which indicated that resistin participated in the occurrence and maintenance of AF. (ii) Plasma resistin level was positively correlated with hs-CRP level. It implied that the occurrence of AF may be related with some inflammatory characteristics of resistin, which suggested that resistin could give rise to inflammatory reaction and participate in the occurrence and maintenance of AF with inflammatory mediators. (iii) Plasma resistin level increased significantly in AF patients complicating hypertension and showed synergistic effect, which suggested possible potentiality of resistin in expressing hypertension and AF independently. Meanwhile, the study also demonstates that hypertension is a risk factor of AF. It might be suspected that resistin can impact on AF via hypertension.
王梅香, 殷屹岗, 陈各才. 血浆抵抗素水平与心房颤动关系的临床研究[J]. 实用心电学杂志, 2016, 25(5): 359-362.
WANG Mei-Xiang, YIN Yi-Gang, CHEN Ge-Cai. Clinical study on the relationship between plasma resistin level and atrial fibrillation. JOURNAL OF PRACTICAL ELECTROCARDIOLOGY, 2016, 25(5): 359-362.
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