心脏性猝死相关疾病基因检测与心电学

郑炜平, 陈海峰, 陈锋, 李峰, 肖建敏, 林开阳

实用心电与临床诊疗 ›› 2015, Vol. 24 ›› Issue (6) : 398-402.

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实用心电与临床诊疗 ›› 2015, Vol. 24 ›› Issue (6) : 398-402. DOI: 10.13308/j.issn.2095-9354.2015.06.003
专题笔谈:心脏性猝死相关疾病与心电学

心脏性猝死相关疾病基因检测与心电学

作者信息 +

The relationship between genetic test of sudden cardiac death related diseases and electrocardiology

Author information +
文章历史 +

摘要

基因检测是继细胞学检测、酶学检测、免疫学检测之后第四代实验室生物学检测技术。与前三代实验室检测技术不同,基因检测可以在疾病的临床症状未发生之前进行早期诊断,为临床疾病尤其是致死性疾病的预防和治疗提供了有利的条件,也是未来基因治疗的前提。遗传性心脏离子通道病和遗传性心肌病是青少年心脏性猝死(sudden cardiac death,SCD)的主要病因,基因检测对心脏性猝死相关疾病诊断、预防和治疗有重要的医疗价值,但在临床中也需要注意基因检测的前提和条件。现对心脏性猝死相关疾病基因检测的应用及其与心电学的联系做简要阐述。

Abstract

Genetic testing is the fourth generation laboratory biological detection technology after cytologic testing, zymologic testing and immunological testing. Unlike the other three generations of biological testing in a laboratory, genetic testing can be used in early diagnosis of a disease before any of the clinical symptoms occur. This technology provides favorable conditions for the prevention and treatment of clinical diseases especially fatal diseases. Genetic testing is also a premise for gene therapy in the future. The main causes pathogens of youth SCD are heritable cardiac channelopathies and heritable cardiomyopathies. Genetic testing is of significantly medical value for diagnosis, prevention and treatment of SCDrelated disease. However, more attention needs to be paid to the premises and conditions of genetic testing.This paper provides brief introduction to the development and application of genetic testing on SCDrelated diseases.

关键词

心脏性猝死 / 心律失常 / 基因检测

Key words

sudden cardiac death / cardiac arrhythmia / genetic testing

引用本文

导出引用
郑炜平, 陈海峰, 陈锋, . 心脏性猝死相关疾病基因检测与心电学[J]. 实用心电学杂志, 2015, 24(6): 398-402 https://doi.org/10.13308/j.issn.2095-9354.2015.06.003
ZHENG Wei-Ping, CHEN Hai-Feng, CHEN Feng, et al. The relationship between genetic test of sudden cardiac death related diseases and electrocardiology[J]. JOURNAL OF PRACTICAL ELECTROCARDIOLOGY, 2015, 24(6): 398-402 https://doi.org/10.13308/j.issn.2095-9354.2015.06.003

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基金

国家自然科学基金资助项目(81470021);国家临床重点专科建设项目(急诊医学2012)


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