Abstract:The effects of holiday syndrome on the human body have received considerable attention. Holiday syndrome essentially derives from negative emotion. It gives rise to multisystem dysfunction, induces arrhythmia, and may aggravate original heart diseases further. The pathogenesis of holiday syndrome is closely related to the imbalance of neuroendocrine regulation, and also associates with the imbalance of autonomic nervous system regulation. Once holiday syndrome has developed, normal state of life will be more or less disturbed, and life is threatened even in severe cases. Therefore, it is very necessary to pay attention to holiday syndrome and make adequate regulation. The most fundamental treatment of holiday syndrome is to start with physiological and psychological regulation. In order to relieve harmful effect of negative emotions on the human body, it is suggested to adopt various methods including the fivesenseorgansregulation method, catharsisrelease method, rational digestion method and mindfulness decompression therapy, and take medical therapeutic regimen if necessary.