Abstract：Catecholaminergic polymorphic ventricular tachycardia(CPVT) is a kind of familial hereditary arrhythmia with a high degree of malignancy. Its clinical manifestations are mainly bidirectional and(or) polymorphic ventricular tachycardia, syncope and sudden death induced by exercise or emotional agitation(adrenalinemediated). The pathogenic genes of CPVT are mainly RyR2 and CASQ2. Calcium release abnormality caused by RyR2 channel dysfunction forms the pathological basis of CPVT. This paper reviews on the mechanism of myocardial repolarization abnormality in CPVT patients. It has been revealed by research that adrenaline stimulation can aggravate irregular and alternate changes of myocardial calcium transient in CPVT patients, and give rise to myocardial repolarization irregularity and increase of QT interval variation, resulting in malignant arrhythmia.
2018, Vol. 28 
