目的  观察抗癌药多柔比星（ADM）对心脏的毒性反应。 方法  对1 088例接受多柔比星化疗患者的心电图改变进行观察和对比。 结果   1 088例患者用多柔比星化疗前心电图均正常，化疗后出现窦性心动过速、窦性心动过缓、房性及室性期前收缩、ST段压低、T波低平、T波倒置、肢导联QRS波群低电压、心房纤颤、房室传导阻滞352例（异常率32.3%）。 结论  多柔比星有较强的毒性作用，而心电图作为一种监测化疗药物对心肌毒性的方法，经济、实用、简便，重复性好，可在临床用于监测药物的心脏副反应。

Objective  To explore the caidiac toxicity of adriamycin（ADM）. Method  ECG of 1 088 cases treated by ADM were analyzed. Results  After the ADM treatment，352 cases of abnormal ECG were found，which included sinus tachycardia，sinus bradycardia，atrial and ventricular contractions，ST- segment depression，T wave low and flat，T-wave inversion，limb lead QRS wave group of low voltage，atrial fibrillation. Conclusion   ADM treatment is accompanied with strong cardiac toxicity，which may be evaluated by ECG .The ECG process is simple and economical，reproducible to provide information about the cardical toxicity of ADM.