Abstract：Objective: To investigate the relation between115A(rs12221497) and-6A(rs11039155) point mutation of liver X receptor α and the patients with coronary heart disease(CHD).Methods: The6A polymorphism in the liver X receptor α gene were detected by using singlelabeled probe technique. Plasma cholesterol, triglyceride, HDL-cholesterol, LDLcholesterol, fasting blood glucose(FBG) were determined in 165 patients with CHD and 191 normal controls. Results: LXR6A(rs11039155) had only one genetype. Randomly selected 22 cases of samples for gene sequencing, suggesting:genetypes of GG homozygote. Conclusion: There was no mutation in liver X receptor α gene6A point in Han population in Jiangsu province.
朱锦，孙建辉，白江涛，罗光华. 江苏地区汉族人群冠心病患者肝X受体基因-6A多态性[J]. 江苏大学学报:医学版, 2014, 24(05): 412-415.
ZHU Jin， SUN Jian-hui， BAI Jiang-tao， LUO Guang-hua. Liver X receptor α gene polymorphisms（6A） of the patients
with coronary heart disease in Han population in Jiangsu province. Journal of Jiangsu University(Medicine Edition), 2014, 24(05): 412-415.
\[1\]Willy PJ, Umesono K, Ong ES， et al. LXR, a nuclear receptor that defines a distinct retinoid response pathway\[J\]. Genes Dev，1995, 9(9):1033-1045.\[2\]Wojcicka G, JamrozWisniewska A, Horoszewicz K，et al. Liver X receptors (LXRs). Part Ⅰ: structure, function, regulation of activity, and role in lipid metabolism\[J\]. Postepy Hig Med Dosw (Online)，2007, 61:736-759.\[3\]Joseph SB, McKilligin E, Pei L，et al.Synthetic LXR ligand inhibits the development of atherosclerosis in mice\[J\]. Proc Natl Acad Sci U S A，2002, 99(11):7604-7609.\[4\]Luo G, Zheng L, Zhang X，et al. Genotyping of single nucleotide polymorphisms using basequenched probe: a method does not invariably depend on the deoxyguanosine nucleotide\[J\]. Anal Biochem，2009, 386(2):161-166.\[5\]Collins FS, Brooks LD, Chakravarti A. A DNA polymorphism discovery resource for research on human genetic variation\[J\]. Genome Res， 1998, 8(12):1229-1231.\[6\]Legry V, Cottel D, Ferrieres J，et al. Association between liver X receptor α gene polymorphisms and risk of metabolic syndrome in French populations\[J\]. Int J Obes (Lond),2008, 32(3):421-428.\[7\]Carlson CS, Eberle MA, Rieder MJ，et al. Additional SNPs and linkagedisequilibrium analyses are necessary for wholegenome association studies in humans\[J\]. Nat Genet，2003, 33(4):518-521.\[8\]Bamshad MJ, Wooding S, Watkins WS，et al.Human population genetic structure and inference of group membership\[J\]. Am J Hum Genet， 2003, 72(3):578-589.\[9\]Li X, Song Y, Han Y, et al. Liver X receptor agonist alleviated high glucoseinduced endothelial progenitor cell dysfunction via inhibition of reactive oxygen species and activation of AMPactivated protein kinase\[J\]. Microcirculation，2012,19 (6):547-553.\[10\]Legry V, Bokor S, Beghin L, et al. Associations between common genetic polymorphisms in the liver X receptor α and its target genes with the serum HDLcholesterol concentration in adolescents of the HELENA Study\[J\]. Atherosclerosis，2011,216 (1):166-169.\[11\]Asztalos BF, Cupples LA, Demissie S，et al.Highdensity lipoprotein subpopulation profile and coronary heart disease prevalence in male participants of the Framingham Offspring Study\[J\]. Arterioscler Thromb Vasc Biol,2004, 24(11):2181-2187.\[12\]Soyama Y, Miura K, Morikawa Y，et al.Highdensity lipoprotein cholesterol and risk of stroke in Japanese men and women: the Oyabe Study\[J\]. Stroke,2003, 34(4):863-868.
2014, Vol. 24 
