Abstract:ST-segment change is an ECG manifestation which is commonly seen in clinical practice and easily misdiagnosed. The reason is that ST-segment is mainly descriptive in ECG report and it is difficult to measure the end of S wave and the beginning of T wave accurately. All of -T changes are not caused by myocardial ischemia since many factors contribute to ST-T changes. It has vital clinical significance to accurately identify predictive ST-T changes for ECG's important diagnostic value on myocardial ischemia. This paper reviews the related basic concepts, generalizes four determining methods of ST-segment depression, summarizes its correspondence analysis and several common ST-depression of special types, analyzes its prognosis and risk stratification, and explains the mechanism, so as to provide concise thinking of analysis and diagnosis for more clinicians.