Abstract：Objective To explore the role of respiratory rate change in regulating the balance of cardiovascular autonomic nerve and its influence on arrhythmia after myocardial ischemia. Methods Seventeen standard laboratory rats including 9 in normal group and 8 in myocardial ischemia model group were conducted with mechanical ventilation by ventilator to change respiratory rates. The fundamental tidal volume was constantly set at 10 mL/kg while respiratory rate changed(increasing by 10% and 20%, and decreasing by 10% and 20% of fundamental respiratory rate). Blood pressure and heart rate were recorded continuously; the influence of respiration rate regulation on heart rate variability(HRV) and blood pressure instant variability(BPIV) was analyzed; the synchronism of respiration rate with changes of heart rate and blood pressure was observed; the effect of reduced respiration rate on HRV in the two groups was evaluated. Results The cyclical changes of RR interval and blood pressure coincided with respiratory rate. The central frequencies of HRV and BPIV were both consistent with that of respiratory power spectral density. The variation trend of respiratory rate was essentially in agreement with that of heart rate and blood pressure, and especially, the variation trend of heart rate and blood pressure was completely identical. Conclusion HRV and BPIV under respiratory regulation correspond with physiological mechanism of respiratory sinus irregularity. It is the secondary effect of RR interval changes and reflects the results of autonomic nervous balance. The frequency of heart beat contributes to the synchronous changes of heart rate and blood pressure. It may reduce the incidence of myocardialischemiainduced arrhythmia to slow respiratory rate.
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2017, Vol. 26 
