Abstract：Newonset atrial fibrillation(NOAF) after acute myocardial infarction(AMI) is a kind of arrhythmia commonly seen after myocardial infarction, with an incidence rate ranging from 5% to 23%. It has been verified by several clinical research that NOAF can significantly increase the mortality during hospitalization of AMI patients or outofhospital longterm risk of death. This paper reviews the pathogenic mechanisms of NOAF after AMI and risk prediction methods in recent years. At present, there is still no enough evidence of evidencebased medicine for the treatment of this kind of arrhythmia, which is especially important for the prevention of NOAF. It is critical for its prevention to understand its pathophysiological mechanism and thus to master the method for identifying the highrisk patients as early as possible.
骆家晨, 戴黎明, 魏毅东. 急性心肌梗死后新发心房颤动的机制及风险预测的研究进展[J]. 实用心电学杂志, 2016, 25(4): 298-302.
LUO Jia-Chen, DAI Li-Ming, WEI Yi-Dong. New insight into the mechanisms of new onset atrial fibrillation after acute myocardial infarction and methods for risk prediction. JOURNAL OF PRACTICAL ELECTROCARDIOLOGY, 2016, 25(4): 298-302.
[1] Podolecki T，Lenarczyk R，Kowalczyk J，et al. Effect of type of atrial fibrillation on prognosis in acute myocardial infarction treated invasively[J].Am J Cardiol，2012，109（12）:1689-1693.[2] Wong CK，White HD，Wilcox RG，et al. Significance of atrial fibrillation during acute myocardial infarction, and its current management: insights from the GUSTO3 trial[J].Card Electrophysiol Rev，2003，7（3）:201-207.[3] 中华医学会心血管病学分会，中华心血管病杂志编辑委员会.急性ST段抬高型心肌梗死诊断和治疗指南[J].中华心血管病杂志，2015，43（5）:380-393.[4] January CT，Wann LS，Alpert JS，et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society[J].J Am Coll Cardiol，2014，64（21）:e1-e76.[5] Batra G，Svennblad B，Held C，et al. All types of atrial fibrillation in the setting of myocardial infarction are associated with impaired outcome[J].Heart，2016，102（12）：926-933.[6] KarlHeinz Kuck.经体表和心内膜标测的转子识别及其对房颤消融的影响[J].实用心电学杂志，2014，23(5): 305-318.[7] Stamboul K，Zeller M，Fauchier L，et al. Incidence and prognostic significance of silent atrial fibrillation in acute myocardial infarction[J].Int J Cardiol，2014，174（3）:611-617.[8] Wi J，Shin DH，Kim JS，et al. Transient newonset atrial fibrillation is associated with poor clinical outcomes in patients with acute myocardial infarction[J].Circ J，2016，80（7）：1615-1623.[9] Asanin M，Vasiljevic Z，Matic M，et al.Outcome of patients in relation to duration of newonset atrial fibrillation following acute myocardial infarction[J].Cardiology，2007，107（3）:197-202.[10] Angeli F，Reboldi G，Garofoli M，et al. Atrial fibrillation and mortality in patients with acute myocardial infarction: a systematic overview and metaanalysis[J].Curr Cardiol Rep，2012，14（5）:601-610.[11] Lubitz SA，Yin X，Rienstra M，et al. Longterm outcomes [JP2]of secondary atrial fibrillation in the community: the Framingham Heart Study[J].Circulation，2015，131（19）:1648-1655.[12] Jabre P，Roger VL，Murad MH，et al. Mortality associated with atrial fibrillation in patients with myocardial infarction: a systematic review and metaanalysis[J].Circulation，2011，123（15）:1587-1593.[13] Rene AG，Généreux P，Ezekowitz M，et al. Impact of atrial fibrillation in patients with STelevation myocardial infarction treated with percutaneous coronary intervention (from the HORIZONSAMI [harmonizing outcomes with revascularization and stents in acute myocardial infarction trial [J].Am J Cardiol，2014，113(2):236-242.[14] Bang CN，Gislason GH，Greve AM，et al.Newonset atrial fibrillation is associated with cardiovascular events leading to death in a first time myocardial infarction population of 89 703 patients with longterm followup: a nationwide study[J].J Am Heart Assoc，2014，3（1）:e000382.[15] Jons C，Jacobsen UG，Joergensen RM，et al. The incidence and prognostic significance of newonset atrial fibrillation in patients with acute myocardial infarction and left ventricular systolic dysfunction: a CARISMA substudy[J].Heart Rhythm，2011，8（3）:342-348.[16] Sinno H，Derakhchan K，Libersan D，et al.Atrial ischemia promotes atrial fibrillation in dogs[J].Circulation，2003，107（14）:1930-1936.[17] Jayachandran JV，Zipes DP，Weksler J，et al. Role of the Na(+)/H(+) exchanger in shortterm atrial electrophysiological remodeling[J].Circulation，2000，101（15）:1861-1866.[18] Alasady M，Abhayaratna WP，Leong DP，et al. Coronary artery disease affecting the atrial branches is an independent determinant of atrial fibrillation after myocardial infarction[J].Heart Rhythm，2011，8（7）:955-960.[19] Karatas MB，Canga Y，ìpek G，et al. Association of admission serum laboratory parameters with newonset atrial fibrillation after a primary percutaneous coronary intervention[J].Coron Artery Dis，2016，27（2）:128-134.[20] Parashar S，Kella D，Reid KJ，et al.Newonset atrial fibrillation after acute myocardial infarction and its relation to admission biomarkers (from the TRIUMPH registry)[J].Am J Cardiol，2013，112（9）:1390-1395.[21] Galvao Braga C，Ramos V，Vieira C，et al. Newonset atrial fibrillation during acute coronary syndromes:predictors and prognosis.[J].Rev Port Cardiol，2014，33(5):281-287.[22] Bahouth F，Mutlak D，Furman M，et al.Relationship of functional mitral regurgitation to newonset atrial fibrillation in acute myocardial infarction[J].Heart，2010，96（9）:683-688.[23] Ravelli F，Allessie M.Effects of atrial dilatation on refractory period and vulnerability to atrial fibrillation in the isolated Langendorffperfused rabbit heart[J].Circulation，1997，96（5）:1686-1695.[24] Bode F，Katchman A，Woosley RL，et al. Gadolinium decreases stretchinduced vulnerability to atrial fibrillation[J].Circulation，2000，101（18）:2200-2205.[25] Psychari SN，Apostolou TS，Sinos L，et al. Relation of elevated Creactive protein and interleukin6 levels to left atrial size and duration of episodes in patients with atrial fibrillation[J].Am J Cardiol，2005，95（6）:764-767.[26] Yoshizaki T，Umetani K，Ino Y，et al. Activated inflammation is related to the incidence of atrial fibrillation in patients with acute myocardial infarction[J].Intern Med，2012，51（12）:1467-1471.[27] Kulik A，Singh JP，Levin R，et al. Association between statin use and the incidence of atrial fibrillation following hospitalization for coronary artery disease[J].Am J Cardiol，2010，105（12）:1655-1660.[28] Guenancia C，Stamboul K，Garnier F，et al. Obesity and newonset atrial fibrillation in acute myocardial infarction: a gender specific risk factor[J].Int J Cardiol，2014，176（3）:1039-1041.[29] Zhang EY，Cui L，Li ZY，et al.High killips class as a predictor of newonset atrial fibrillation following acute myocardial infarction: systematic review and metaanalysis[J].Chin Med J(Engl)，2015，128（14）:1964-1968.[30] Dart AM，Du XJ，Kingwell BA. Gender, sex hormones and autonomic nervous control of the cardiovascular system[J].Cardiovasc Res，2002，53（3）:678-687.[31] Dorje T，Wang X，Shao M，et al.Plasma Nterminal probrain natriuretic peptide levels predict newonset atrial fibrillation in patients with acute myocardial infarction[J].Int J Cardiol，2013，168（3）:3135-3137.[32] Asanin M，Stankovic S，Mrdovic I，et al. Btype natriuretic peptide predicts newonset atrial fibrillation in patients with STsegment elevation myocardial infarction treated by primary percutaneous coronary intervention[J].Peptides，2012，35（1）:74-77.[33] Aronson D，Boulos M，Suleiman A，et al. Relation of Creactive protein and newonset atrial fibrillation in patients with acute myocardial infarction[J].Am J Cardiol，2007，100（5）:753-757.[34] Ren Y，Zeng RX，Li JJ，et al. Relation of Creactive protein and newonset atrial fibrillation in patients with acute myocardial infarction: A systematic review and metaanalysis[J].Int J Cardiol，[JP]2015，190:268-270.[35] Jons C，Joergensen RM，Hassager C，et al. Diastolic dysfunction predicts newonset atrial fibrillation and cardiovascular events in patients with acute myocardial infarction and depressed left ventricular systolic function: a CARISMA substudy[J]. Eur J Echocardiogr，2010，11（7）:602-607.[36] Antoni ML，Bertini M，Atary JZ，et al.Predictive value of total atrial conduction time estimated with tissue Doppler imaging for the development of newonset atrial fibrillation after acute myocardial infarction[J].Am J Cardiol，2010，106（2）:198-203.[37] Rosiak M，Ruta J，Bolińska H. Usefulness of prolonged Pwave duration on signal averaged ECG in predicting atrial fibrillation in acute myocardial infarction patients[J].Med Sci Monit，2003，9（8）:Mt85-88.[38] van Diepen S，Siha H，Fu Y，et al. Do baseline atrial electrocardiographic and infarction patterns predict newonset atrial fibrillation after ST-elevation myocardial infarction? Insights from the assessment of pexelizumab in acute myocardial infarction trial[J].J Electrocardiol，2010，43（4）:351-358.[39] Zhang X，Li G，Zhao Z，et al. The value of CHADS2 score in predicting newonset atrial fibrillation in Chinese patients with acute myocardial infarction[J].Int J Cardiol，2014，176（3）:1235-1237.
2016, Vol. 25 
