Abstract：Objective To investigate the clinical characteristics, risk factors and prognosis of patients with hypertrophic cardiomyopathy(HCM) accompanied with atrial fibrillation (AF). Methods Outpatients or inpatients with HCM were selected, and divided into AF group and nonAF group based on the presence or absence of AF. The clinical features and prognosis of the two groups were observed. Multiple Logistic regression analysis was applied in exploring the risk factors of HCM patients complicating AF. ResultsA total of 144 HCM patients are enrolled in our study, with 32 patients (22.2%) in the AF group and 112 patients (77.8%) in the non-AF group. Multiple Logistic regression analysis reveals that enlarged left atrial diameter (LAD, OR=2.013, P=0.004) and reduced left ventricular ejection fraction (LVEF, OR=0.920, P<0.01) are independent risk factors for HCM patients with AF. During an average follow-up period of two years and three months, the readmission rate of patients in the AF group is significantly higher than that in the non-AF group (P＜0.05); there is no significant difference in the primary endpoints (death) or other secondary endpoints (heart failure and thrombembolia) between the two groups (P＞0.05). Conclusion The readmission rate of HCM patients complicated by AF is significantly increased. The enlarged LAD and reduced LVEF are independent risk factors for complicated AF among HCM patients.
