Abstract：Objective To explore the effect of ivabradine on QT interval and sinus rhythm in patients with chronic heart failure ( HF). Methods A total of 179 patients with chronic HF were selected as the research subjects. They underwent 12-lead synchronous ambulatory electrocardiography ( AECG) examination, and re-examination of AECG 30-45 days after oral administration of ivabradine. The changes of QT interval and heart rate before and after medication were compared. Results A total of 143 patients complete clinical follow-up and are enrolled in this study. After oral administration of ivabradine, the maximum QT interval [(467. 9 ± 62. 6)ms vs. (473. 6±63. 4) ms], the maximum QTc [(489. 3±56. 0) ms vs. (496. 6±55. 4) ms], the average QT interval [(390. 5±41. 1) ms vs. (398. 6±43. 7) ms], the average QTc [(417. 2±31. 4) ms vs. (414. 4±36. 9) ms], and the minimum QTc [(377. 5± 36. 0) ms vs. (361. 3±37. 0) ms] of all the 143 patients are significantly different from those before medication (P<0. 01). The minimum QT interval [(348. 3 ± 42. 8) ms vs. (349. 6±38. 9) ms] does not vary significantly before and after medication ( P > 0. 05). The differences of the minimum heart rate [(50. 3±8. 6) times per minute vs. (47. 7±7. 8) times per minute], the average heart rate [(69. 9±11. 7) times per minute vs. (64. 9±10. 6) times per minute], and the maximum heart rate [(116. 6±23. 1) times per minute vs. (109. 0±20. 1) times per minute] are all statistically significant before and after medication (P<0. 01). During the follow-up period, there is no incidence of ventricular arrhythmia or sudden death. Conclusion Ivabradine could significantly shorten the maximum QT interval / QTc and the average QT interval, and slow down heart rate. Its clinical application is safe and effective.
邸成业,王群,吴岩熹,李龙雨,张岩,林文华. 伊伐布雷定对慢性心力衰竭患者 QT 间期和心率的影响[J]. 实用心电学杂志, 2023, 32(6): 386-394.
DI Chengye,WANG Qun, WU Yanxi, LI Longyu, ZHANG Yan, LIN Wenhua. Effect of ivabradine on QT interval and heart rate in patients with chronic heart failure. JOURNAL OF PRACTICAL ELECTROCARDIOLOGY, 2023, 32(6): 386-394.
