Abstract：The conventional pacing sites of right ventricular pacing are the right ventricular septum and apex. However, they are not physiological pacing sites, which could lead to asynchronous ventricular contraction, and further pacemaker-induced cardiomyopathy and increased hospitalization rate of patients with heart failure. His bundle pacing (HBP) simulates the electrical activation sequence of the normal ventricle, and is a physiological mode of pacing. In recent years, the clinical applications of HBP in patients with heart failure are increasing year by year. Moreover, HBP yields significant benefits in clinical practice, and becomes a hot topic of research at present. From the aspects including the anatomy and electrophysiology of His bundle, this paper reviews the research status of HBP and its progress applied in patients with heart failure.
