Abstract：Objective To investigate the clinical efficacy of Shensong Yangxin (SSYX) capsule combined with metoprolol on heart rate-related premature ventricular complex(PVC). Methods Three hundred PVC patients with symptoms were selected, and randomized into combined medication group and control group—in the former group a combined metoprolol and SSYX capsules were simultaneously prescribed while in the latter group metoprolol was took alone. The Holter monitoring indexes and symptom alleviation rate were analyzed before and after the treatment. The efficacy of the combined medication was compared among fast heart rate-dependent PVC (F-HR-PVC), heart rate-independent PVC (I-HR-PVC) and slow heart ratedependent PVC (S-HR-PVC). ResultsCompared with the control group, the frequency of PVCs during 24 hours in the combined medication group is significantly declined\[(5 536.22±3 826.35) times vs (4 348.59±3 267.48) times, P=0.037], and so is the PVC load[(5.82±4.29)% vs (3.77±3.37)%, P=0.018］. Subgroup analysis shows that the clinical symptom relief rate and the number of patients with a reduced PVC frequency by 50% both significantly increase among patients with I and S-HR-PVC from the combined medication group, if compared with the control group (P＜0.05); the effectiveness rate on patients with F-HR-PVC does not vary significantly between the two groups. ConclusionCompared with metoprolol used alone, the effectiveness rate of SSYX capsule combined with metoprolol proves to be significantly higher, especially on those with I and S-HR-PVC.
叶敏霞，周小军，张玲娟，苏红. 参松养心胶囊联合美托洛尔治疗心率相关性室性早搏的临床研究[J]. 实用心电学杂志, 2020, 29(6): 417-421.
Ye Min-xia, Zhou Xiao-jun, Zhang Ling-juan,Su Hong. Clinical study on the treatment of heart rate-related premature ventricular contraction with Shensong Yang-xin capsule combined with metoprolol. JOURNAL OF PRACTICAL ELECTROCARDIOLOGY, 2020, 29(6): 417-421.
