Abstract：ObjectiveTo explore the association of subclinical hyperthyroidism (SCH) with atrial fibrillation (AF).MethodsThree hundred and eightyeight patients with SCH diagnosed by thyroid function examination in our hospital were selected as SCH group, 388 inpatients with hyperthyroidism were selected randomly as hyperthyroidism group while 388 inpatients with normal thyroid function were selected randomly as normal group. General information,TSH levels and incidence of atrial fibrillation were compared among the three groups. Serum TSH levels were compared between AF group and nonAF group. Correlation between TSH level and incidence of AF was analyzed with the methods of Spearman. Logistic regression analyses were performed to identify the independent risk factors for AF. Results① There were significant differences in the incidence of AF among the three groups (3.22% vs. 17.78% vs. 12.90%，P＜0.05); ② TSH level of AF group was significantly lower than nonAF group [0.14(0.13，0.23) vs. 0.20(0.09，2.59), P＜0.01]；③ Spearman sequential correlation analysis demonstrated that TSH was negatively correlated with AF, r=-0.162 (P＜0.01)； ④ Logistic analyses demonstrated that age, SCH and diabetes were independently associated with AF (OR=1.29, 2.03, 1.79, P＜0.05). ConclusionSCH was independently associated with AF. Early diagnosis and treatment of AF are advised in patients with SCH.
