Abstract:Objective To observe the relationship between blood pressure instant variability(BPIV), heart rate variability(HRV) and respiration in rabbits separately before and after hibateral vagus nerves cutting and respiratory arrest under respiratory rate regulation. Methods Ten standard experiment rabbits were selected and rabbit model of mechanical ventilation was established. The rabbits were conducted with mechanical ventilation under anesthesia by ventilator, with a constant tide volume of 10 mL/kg and respiratory rate of 70 times/min. Continuous recording of ECG, respiration and blood pressure was performed separately before and after hibateral vagus nerves cutting and respiratory arrest. The relationship between changes of HRV, BPIV and respiratory rate was analyzed. Results Before cutting hibateral vagus nerves, R-R interval and BP-BP were synchronized with the respiratory phase, with the same trend. The central frequencies of HRV and BPIV were both consistent with the central frequency of respiratory power spectral density. After cutting hibateral vagus nerves, the synchronous periodic change and trend consistency of R-R interval, BP-BP and respiration was destroyed; the central frequency of HRV and BPIV almost disappeared and was inconsistent with the central frequency of respiratory power spectral density; HRV and BPIV disappeared after respiratory arrest. Conclusion The changes of HRV and BPIV under respiratory rate regulation accord with the physiological mechanism of respiratory sinus arrhythmia. It is the secondary effect of R-R interval change which reflects the result of balance adjustment of autonomic nerve. It also coincides with the mechanism of HeringBreuer reflex induced by excitation of the tow receptor in the lung.
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