Abstract：ObjectiveTo investigate the correlation between heart rate variability(HRV) indexes and coronary artery stenosis. MethodsNinetysix patients specifically diagnosed with coronary artery stenosis by coronary angiography were enrolled in this study. They had been admitted to our hospital from December 2015 to December 2017. According to the grading system of coronary artery stenosis(Gensini score), they were divided into mild stenosis group(31 cases), moderate stenosis group (33 cases) and severe stenosis group(32 cases). All patients underwent 24hour ambulatory electrocardiography examination. We compared the HRV indexes among the 3 groups, including standard deviation of NN intervals(SDNN), standard deviation of all 5min averaged intervals(SDANN), root mean square of successive differences in RR interval(rMSSD), percentage of RR intervals differing more than 50 ms from the preceding one(pNN50), and the ratio of low frequency to high frequency(LF/HF). Pearson linear correlation analysis was used to reveal the correlation between HRV and the severity of coronary artery stenosis(Gensini score). ResultsSDNN, SDANN, rMSSD and pNN50 of mild stenosis group were higher than those of moderate and severe stenosis groups while these indexes of moderate stenosis group were higher than those of severe stenosis group, all with statistically significant differences(P<0.05). The LF/HF and Gensini scores of mild stenosis group were lower than those of moderate and severe stenosis groups while these indexes of moderate stenosis group were lower than those of severe stenosis group, all with statistically significant differences(P<0.05). Pearson linear correlation analysis revealed that SDNN, SDANN, rMSSD and pNN50 were negatively correlated with Gensini score(r=-0.890,-0.877,-0.843 and -0.802;P<0.05). There was a positive correlation between LF/HF and Gensini score(r=0.872,P<0.05). ConclusionHRV indexes were different among the patients with varied severity of coronary artery stenosis. The more severe the coronary stenosis, the lower were SDNN, SDANN, rMSSD and pNN50, and the higher was LF/HF, and vice versa. HRV indexes were strongly correlated with the degree of coronary stenosis.
2018, Vol. 28 
