Abstract：Objective To explore the characteristics of heart rate variability(HRV) and its clinical significance for patients with functional dyspepsia.MethodsThe monitoring of 24-hour ambulatory electrocardiography(AECG) was carried out on 80 patients with functional dyspepsia(FD group), 66 patients with duodenal ulcer(DU group) and 60 cases of healthy people as control group.Based on AECG, we made HRV analysis in time and frequency domain.Results①The indexes of SDNN, rMSSD, PNN50, LF and HF in FD group were lower than those of the control group with statistically significant differences(P＞0.05) while there was also statistical significance(P＜0.01) in the difference of SDANN and ULF. Compared with the control group, the index of LF/HF applied in evaluating the balance of sympathetic nerve and pneumogastric nerve significantly increased(P＜0.05) in FD group. ②Compared with the control group, the differences of SDNN, SDANN, ULF, LF and LF/HF in DU group weren’t statistically significant(P＞0.05) while rMSSD, PNN50 and HF increased significantly and the differences were statistically significant(P<0.05). ③Compared with DU group, all of the other indexes in FD group decreased significantly and the difference was statistically significant(P<0.05) except for the increase of LF/HF.ConclusionThere are significant changes in heart rate variability of patients with functional dyspepsia, accompanied by autonomic nervous dysfunction which is evidenced by decreased tension of pneumogastric nerve and enhanced excitability of sympathetic nerve. The HRV detection proves some clinical reference value for comprehensive diagnosis of functional dyspepsia.
2014, Vol. 23 
