［摘要］目的: 研究腹膜透析患者的血Na浓度与预后的相关关系。方法: 回顾性分析在本院接收持续不卧床腹膜透析治疗的119例患者临床资料，按血Na分为Na<135.5 mmol/L组与Na≥135.5 mmol/L组。连续观察36个月。采用KaplanMeier法比较两组患者生存率，Cox比例风险模型分析血Na浓度与预后的关系。 结果： 与Na≥135.5 mmol/L组比较，Na<135.5 mmol/L组3年生存率明显下降（χ2=37.08， P=0.000）。Cox比例风险模型结果显示，与Na≥135.5mmol/L组比较，Na<135.5 mmol/L组患者死亡风险增加（风险比：1.122， 95%CI：1.043～1.209）。患者年龄、血肌酐和血Na浓度为不良肾脏预后的独立危险因素。结论： 血Na浓度水平低的腹膜透析患者生存率较低，血Na浓度水平对腹膜透析患者长期预后的评估有较好的价值。
Abstract
［Abstract］Objective： To evaluate the association between plasma sodium and prognosis in peritoneal dialysis patients. Methods： A total of 119 incident peritoneal dialysis were retrospectively selected, and then were followedup by 36 months or until death. The patients were divided into Group Na<135.5 mmol/L and Group Na≥135.5 mmol/L. The patients′ survival rates were analysied by KaplanMeier analysis. Cox proportional hazards analyses were used for elucidating relationship between plasma sodium and allcause mortality in 119 peritoneal dialysis patients. Results： The overall survival rate in Group Na<135.5 mmol/L was significantly lower than Group Na≥135.5 mmol/L (χ2=37.08，P=0.000). By application of Cox proportional hazard model, hyponatremia was independently associated with allcause mortality(HR:1.122， 95%CI:1.043-1.209). Age, serum creatinine and plasma sodium were significantly correlated with poor renal prognosis. Conclusion： Peritoneal dialysis patients with hyponatremia have poor outcome,and serum sodium level may be helpful to predict the patient survival.
关键词
血钠 /
腹膜透析 /
生存分析
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