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JOURNAL OF PRACTICAL ELECTROCARDIOLOGY
 
2021 Vol.30 Issue.4
Published 2021-08-28

226
2021 Vol. 30 (4): 226-226 [Abstract] ( 34 ) [HTML 1KB] [ PDF 125851KB] ( 680 )
227
2021 Vol. 30 (4): 227-227 [Abstract] ( 23 ) [HTML 1KB] [ PDF 10441KB] ( 484 )
228
2021 Vol. 30 (4): 228-228 [Abstract] ( 24 ) [HTML 1KB] [ PDF 326KB] ( 471 )
229 Pulmonary hypertension and cellular metabolism
HU Mei1,2, LI Dehong3, SU Hongling2,GAO Jinxia4, CAO Yunshan2
Pulmonary hypertension (PH) is a progressive disease characterized by vascular stiffness and altered cellular metabolism. The progressive remodeling of the pulmonary arteries in PH patients causes progressive elevation of pulmonary vascular resistance, eventually leading to right heart failure and even death. Although PH has been extensively studied, the exact pathogenesis has not been fully elucidated. In recent years, studies have found that the metabolic changes of pulmonary vascular cells are related to the pathogenesis of PH, and abnormal metabolism of pulmonary vascular cells (such as smooth muscle cells and endothelial cells) is present in PH patients. The metabolic changes of these cells may result in damage of pulmonary vascular cell and pulmonary vascular remodeling. This article reviews the role metabolic changes of pulmonary vascular cells plays in the development of PH.
2021 Vol. 30 (4): 229-234 [Abstract] ( 68 ) [HTML 1KB] [ PDF 44251KB] ( 614 )
235 Research progress in right ventricular damage caused by chemotherapy
LI Lili1, WANG Aqian2, CHEN Yaling2, JIA Mengfei2, CAO Yunshan2
Chemotherapeutic drugs could cause cardiovascular complications. Previous studies focused on the left ventricle, ignoring the right ventricle. Recent studies have shown that chemotherapeutic druginduced heart injury usually synchronously involves both the right ventricle and the left ventricle, and therefore right ventricular remodeling should not be ignored. Anthracyclines, trastuzumab, etc. could significantly affect the structure and function of the right ventricle. The mechanism of right ventricular remodeling caused by chemotherapeutic drugs is not completely clear at present. It may be related to the direct myocardial injury, oxidative stress, endothelial dysfunction and pulmonary circulation damage caused by chemotherapeutic drugs. This article reviews on the effects of chemotherapeutic drugs on right ventricular remodeling.
2021 Vol. 30 (4): 235-241 [Abstract] ( 47 ) [HTML 1KB] [ PDF 7220KB] ( 671 )
242 Application of routine electrocardiogram examination in the diagnosis and evaluation of pulmonary hypertension
LIU Di1, DENG Mingjun2, WANG Aqian2, CAO Yunshan2
Pulmonary hypertension(PH) is a pathophysiological state in which pulmonary vascular resistance progressively increases due to the contraction and pathological remodeling of pulmonary arterioles, eventually  evolving into  right heart failure and death. Right heart catheterization  is the gold standard for the diagnosis of PH, whereas it is invasive and risky of potential complications. Electrocardiogram (ECG) as a convenient routine examination plays an important role in guiding the diagnosis, and treatment and prognosis evaluation of PH, although it can not directly reflect the  level of pulmonary artery pressure.
2021 Vol. 30 (4): 242-245 [Abstract] ( 48 ) [HTML 1KB] [ PDF 869KB] ( 703 )
246 Value of Lorenz scatter plot in predicting the prognosis of patients with acute myocardial infarction
GUO Chao, ZHANG Hui, CHEN Min
Objective  To investigate the relationship between morphological characteristics of Lorenz scatter plot and the prognosis among patients with acute myocardial infarction (AMI). Methods  A total of 80 patients with AMI  were selected as the research objects. All the patients underwent ambulatory electrocardiography examination after being definitely diagnosed. The obtained data were analyzed in the Lorenz scatter plot method. According to the follow-up results after treatment, the patients were divided into good prognosis group and poor prognosis group. The incidence of arrhythmias and the distribution characteristics of Lorenz scatter plot were compared between the two groups, and the correlation between the prognosis and the characteristics of  Lorenz scatter plot was analyzed.  ResultsAmong the 80 patients with AMI, the incidence of occasional premature supraventricular  beats is the highest, reaching 31.25% while the incidence of RR interval>2.5 s is the lowest, reaching 2.50%. After one year of follow-up, 54 cases are divided into the good prognosis group and 26 cases are divided into the poor prognosis group. The incidence of occasional premature supraventricular beats, frequent premature supraventricular beats, occasional premature ventricular beats (PVB), frequent PVB, and conduction block in the good prognosis group are significantly lower than those in the poor prognosis group with statistically significant differences (P<0.05). There is no significant difference in the incidence of atrial fibrillation and RR interval>2.5 s between the two groups (P>0.05). In the poor prognosis group, the proportion of fanshaped, three and fourdistributed, irregular, complex, and short rodshaped Lorenz scatter plot are significantly higher than those in the good prognosis group. The proportion of baseball bat and cometshaped distributed Lorenz scatter plot along the 45° line are significantly lower than those in the good prognosis group (P<0.05). Spearman correlation analysis shows that  the prognosis is significantly related to the distribution of Lorenz scatter plots (r=0.338, P=0.002). AMI patients featured by baseball bat and cometshaped distributed Lorenz scatter plot have better prognosis. Conclusion  Lorenz scatter plot has important value in predicting the prognosis of AMI patients.
2021 Vol. 30 (4): 246-252 [Abstract] ( 38 ) [HTML 1KB] [ PDF 20149KB] ( 528 )
253 Diagnostic value of treadmill exercise test and coronary computed tomographic angiography on coronary heart disease
ZHANG Jianchun1,2, WANG Xinkang1,2
Objective  To study the value of treadmill exercise test (TET) and coronary computed tomographic angiography (CCTA) in the diagnosis of coronary heart disease (CHD). Methods  A total of 118 patients with suspected CHD in our hospital were selected as research subjects, and performed TET, CCTA and coronary angiography (CAG) within one month. The examination results of TET and CCTA were analyzed with CAG results as diagnostic gold standard. ResultsThe detection rate of severe stenosis lesions by TET is significantly higher than that of moderate stenosis lesions  (P<0.05). The detection rate of single and multivessel lesions does not vary significantly (P>0.05). There is no significant difference in the detection rate of coronary artery stenosis degree, and single and multi-vessel lesions by using CCTA (P>0.05). The sensitivity and specificity of TET in the diagnosis of CHD are 81.3% and 81.4%, respectively while the rates of CCTA are separately 90.7% and 79.1%. The sensitivity and specificity of a combination of TET and CCTA are 96.0% and 72.1%, respectively. Conclusion  Both TET and CCTA have high sensitivity and specificity in the diagnosis of CHD, which can be used as routine examinations among patients with suspected CHD. Combined examination helps to improve diagnostic sensitivity  and avoid missed diagnosis.
2021 Vol. 30 (4): 253-255 [Abstract] ( 35 ) [HTML 1KB] [ PDF 900KB] ( 701 )
256 Clinical effect of sacubitril/valsartan on patients with acute myocardial infarction complicating heart failure
ZHANG Xianlin1, HUANG Juan2, LU Qiao1, CHEN Mengmeng1, HUANG Yuli1, TANG Bi1, ZHANG Heng1
Objective  To investigate the clinical efficacy and safety of sacubitril/valsartan (LCZ696) on patients with acute myocardial infarction complicating heart failure. Methods  We selected 120 patients with acute myocardial infarction complicating heart failure admitted in our hospital. Among them, 58 cases were treated with LCZ696 and conventional drugs  as the intervention group while 62 cases only received conventional drug treatment as the control group. After 6 months of follow-up, the levels of NT-proBNP, creatinine and serum potassium, echocardiographic results, adverse reactions, major adverse cardiovascular events (MACEs), and quality of life were compared between the two groups before and after treatment. Results  After  treatment, the Minnesota living with heart failure questionnaire (MLHFQ) score, left ventricular end diastolic diameter (LVEDd) and NT-proBNP level in the intervention group and the control group are significantly lower than those before treatment; the above indexes in the intervention group are significantly lower than those in the control group  (P<0.05). After treatment, left ventricular ejection fraction (LVEF) increases; LVEF of the intervention group is significantly higher than that of the control group  (P<0.05). The rate of readmission due to heart failure and the MACEs incidence of the intervention group are significantly lower than those of the control group  (P<0.05). The incidence of adverse reactions does not vary significantly between the two groups (P>0.05). After treatment, there is no significant increase in renal function creatinine and serum potassium levels (P>0.05). Conclusion   For the patients with acute myocardial infarction complicating heart failure, LCZ696 is safe, reliable, and  can improve the prognosis. It is worthy of being promoted in clinical practice.
2021 Vol. 30 (4): 256-260 [Abstract] ( 65 ) [HTML 1KB] [ PDF 874KB] ( 787 )
261 Impact of  measurement methods of single lead and synchronous 12-lead on P-wave duration
PAN Yewei1, ZHU Jinxiu2, LI Zexin1, BAO Zhijun1, YANG Peixuan3, QIN Haiou1, LU Xilie2, TAN Xuerui4
Objective  To explore the impact of two measurement methods of single lead and synchronous 12-lead on P-wave duration. MethodsWe selected healthy adults without structural and functional abnormalities,  or definite disease implied by echocardiography examination. Their P-wave duration in single lead and synchronous 12-lead electrocardiogram (ECG) were separately measured.   P-wave duration of the two measurement methods  was compared. Results  A total of 203 subjects are enrolled in the study with an average age of (39.51±10.08)years old. The P-wave duration measured by synchronous 12-lead ECG [109(102,116)ms] is significantly longer than that measured by lead Ⅱ [97(90,102)ms] and lead V1[86(76,96)ms] (P<0.01). Without difference in sex, these results are still statistically different (P<0.01).  In the synchronous 12lead measurement method, the P-wave duration  of 33 subjects (16.26%) is ≥120 ms. Conclusion  P-wave duration is significantly varied if measured by the two measurement methods of single lead and synchronous 12-lead.  The synchronous 12-lead measurement method includes all the parameters of multiple leads. It can more fully represent the P-wave duration, and its measurement results are more accurate.  Therefore, synchronous 12-lead ECG is recommended to measure P-wave duration.
2021 Vol. 30 (4): 261-264 [Abstract] ( 54 ) [HTML 1KB] [ PDF 1133KB] ( 579 )
265 Manifestation and correlation between heart rate deceleration capacity and heart rate variability in patients with silent myocardial ischemia
PENG Yingxiu, YU Yinggen
Objective  To investigate the value of heart rate deceleration capacity (DC), heart rate deceleration runs (DRs) and heart rate variability (HRV) indexes  in the auxiliary diagnosis of silent myocardial ischemia (SMI). Methods  A total of 65 SMI patients who had been admitted and treated in our hospital were selected as the observation group while 65 healthy controls during the same period were enrolled as the control group. Both groups were monitored by 24hour ambulatory electrocardiography. The  values of DC, DRs and HRV indexes of the two groups were compared, and the correlation among these indexes were analyzed. Results   The values of DC, DR4,  DR8, SDANN, rMSSD and pNN50  in the observation group are lower than those in the control group (P<0.05) . There is significant positive correlation between DC, DR2, DR4, DR8, and SDNN, SDANN, rMSSD, pNN50 in the observation group (P<0.05). Conclusion  Compared with healthy people, the levels of DC, DRs and HRV among SMI patients are significantly lower; DC and DRs values are significantly positively correlated with HRV values. Testing of DC, DRs and HRV indexes can be applied as an auxiliary method for screening  SMI patients.
2021 Vol. 30 (4): 265-268 [Abstract] ( 56 ) [HTML 1KB] [ PDF 855KB] ( 812 )
269 Correlation between P-wave characteristic ECG indexes and occurrence of paroxysmal atrial fibrillation in patients with different left atrial diameters
SUN Yu1, WANG Qingyi2, ZHU Na1
Objective  To explore the correlation between P-wave characteristic ECG indexes and the occurrence of paroxysmal atrial fibrillation (PAF) in patients with different left atrial diameters (LADs). Methods  A total of 75 PAF patients were selected as the observation group. According to LAD, they were divided into group A (LAD≥40 mm, 16 cases), group B (35 mm≤LAD<40 mm, 25 cases) and group C (LAD<35 mm, 34 cases). Another 30 nonPAF people accepting physical examinations in our hospital during the same period were selected as the control group. ECG examination was performed in the above groups. The minimum Pwave duration (Pmin), the maximum P-wave duration (Pmax) and P-wave terminal force in lead V1 (PtfV1 ) were compared between the observation group and the control group. The indexes of Pmin, Pmax and PtfV1  were compared among the subgroup A, B and C in the observation group. The correlation between P-wave characteristics of ECG in patients with different LADs and the occurrence of PAF was analyzed with Pearson correlation coefficient. The ROC curve was used to evaluate the diagnostic value of P-wave characteristics of ECG for PAF. ResultsCompared with the control group, Pmin of the observation group significantly decreases while Pmax and PtfV1 significantly increase (P<0.05). With the increase of LAD, Pmin gradually decreases while Pmax and PtfV1 gradually increase among the three subgroups of the observation group (P<0.05); Pmin of PAF patients with different LADs is negatively related to LAD while Pmax and PtfV1 are positively related to LAD (P<0.05). In the diagnosis of PAF, the sensitivity, specificity, accuracy, positive and negative predictive value, and area under curve of the joint detection of Pmin, Pmax and PtfV1 are all significantly higher than those detected by any single index of the above (P<005). ConclusionT  he P-wave ECG characteristics of patients with different LADs are closely related to the occurrence of PAF.
2021 Vol. 30 (4): 269-273 [Abstract] ( 35 ) [HTML 1KB] [ PDF 979KB] ( 659 )
274 Discussion about  ECG with de Winter ST-T changes
LUO Dan1,2, YIN Chun’e2, WANG Fujun1,2
It is still controversial on the naming, criminal vascular location and diagnosis of the ECG with de Winter STT changes. Based on  related references, this paper shares authors’ opinions on the above disputed problems.
2021 Vol. 30 (4): 274-278 [Abstract] ( 45 ) [HTML 1KB] [ PDF 12951KB] ( 534 )
279 Impact of cardiac rehabilitation on atrial fibrillation: Current perspectives
WU Ying, LI Xiaoyan, WANG Ruxing
Atrial fibrillation (AF) is a kind of common arrhythmia associated with increased risks of stroke, heart failure and cardiovascular death, which  is seriously endangering human health. Cardiac rehabilitation has  little  been applied in the treatment of  AF at present, although it is recommended in the comprehensive treatment of coronary heart disease, heart failure and other chronic heart diseases for its efficacy in improving  patients exercise capacity, quality of life and prognosis. This article systematically reviews the roles of cardiac rehabilitation among AF patients and the latest research progress.
2021 Vol. 30 (4): 279-283 [Abstract] ( 51 ) [HTML 1KB] [ PDF 947KB] ( 564 )
284 Relationship between superior vena cava and atrial fibrillation
LIN Mingkuan
Atrial fibrillation (AF) is the most common persistent arrhythmia. Studies have shown that AF is triggered or driven by the superior vena cava in parts of patients, and superior vena cava isolation proves to be an effective therapy for this type of AF. This article reviews the anatomy of the superior vena cava, the mechanism of AF originated from the superior vena cava, electrophysiological characteristics, ablation and prevention of complications.
2021 Vol. 30 (4): 284-287 [Abstract] ( 47 ) [HTML 1KB] [ PDF 845KB] ( 763 )
288 Interaction between autophagy and apoptosis in diabetic cardiomyopathy
WU Shenglin1, ZHU Jinxiu2, TAN Xuerui3
Diabetic cardiomyopathy (DCM) is one of major cardiovascular complications of diabetes mellitus. Oxidative stress, mitochondrial dysfunction, inflammation, myocardial fibrosis, apoptosis and autophagy are all involved in the occurrence and development of DCM. More and more evidences show that the levels of cardiomyocyte apoptosis and autophagy change through the occurrence and development of DCM, and the relationship between them may play an important role in the pathogenesis of DCM. At present, there is no effective prevention strategy or therapeutic target for DCM. It is of great significance to thoroughly illustrate the interaction between autophagy and apoptosis in the treatment of DCM. This paper reviews the importance of autophagy and apoptosis, and the interaction between them in the pathogenesis of DCM.
2021 Vol. 30 (4): 288-292 [Abstract] ( 38 ) [HTML 1KB] [ PDF 1611KB] ( 703 )
293 Mechanism of heart rate variability and  research advance in its relevance to cardiovascular diseases
LI Jingxiu1, ZHANG Fujun2, LIU Xian3, LI Xueqi3
Heart rate variability (HRV) is an index which can accurately reflect the activity of cardiac autonomic nervous system. By improving HRV analysis via ambulatory electrocardiographic examination, the sympathetic nerve and vagus nerve tension, and their balance state can be quantitatively evaluated with a combination of time and frequencydomain analysis. Based on the regulatory mechanism of HRV, this review intends to interpret the clinical significance of time and frequencydomain analysis indexes. Combined with recent clinical researches and metaanalysis related to HRV in the fields of coronary atherosclerotic cardiopathy, primary hypertension, heart failure and atrial fibrillation, this paper also reviews the clinical application of HRV testing and analysis in the field of cardiovascular diseases.
2021 Vol. 30 (4): 293-296 [Abstract] ( 45 ) [HTML 1KB] [ PDF 862KB] ( 718 )
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2021 Vol. 30 (4): 297-300 [Abstract] ( 51 ) [HTML 1KB] [ PDF 19808KB] ( 485 )
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2021 Vol. 30 (4): 301-304 [Abstract] ( 49 ) [HTML 1KB] [ PDF 44335KB] ( 548 )
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2021 Vol. 30 (4): 305-305 [Abstract] ( 29 ) [HTML 1KB] [ PDF 600KB] ( 508 )
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2021 Vol. 30 (4): 306-306 [Abstract] ( 31 ) [HTML 1KB] [ PDF 715KB] ( 515 )
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2021 Vol. 30 (4): 307-307 [Abstract] ( 23 ) [HTML 1KB] [ PDF 841KB] ( 495 )
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