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Abstract Objective To explore the impact of two measurement methods of single lead and synchronous 12-lead on P-wave duration. MethodsWe selected healthy adults without structural and functional abnormalities, or definite disease implied by echocardiography examination. Their P-wave duration in single lead and synchronous 12-lead electrocardiogram (ECG) were separately measured. P-wave duration of the two measurement methods was compared. Results A total of 203 subjects are enrolled in the study with an average age of （39.51±10.08）years old. The P-wave duration measured by synchronous 12-lead ECG ［109（102,116）ms］ is significantly longer than that measured by lead Ⅱ ［97（90，102）ms］ and lead V1［86（76，96）ms］ (P<0.01). Without difference in sex, these results are still statistically different (P<0.01). In the synchronous 12lead measurement method, the P-wave duration of 33 subjects (16.26%) is ≥120 ms. Conclusion P-wave duration is significantly varied if measured by the two measurement methods of single lead and synchronous 12-lead. The synchronous 12-lead measurement method includes all the parameters of multiple leads. It can more fully represent the P-wave duration, and its measurement results are more accurate. Therefore, synchronous 12-lead ECG is recommended to measure P-wave duration.
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