ObjectiveTo retrospectively explore the efficacy of felodipine combined with bisoprolol in the treatment of hypertension complicating coronary heart disease (CHD), and their effect on hemorheology, inflammationrelated indicators and vascular endothelial function. MethodsWe selected 100 patients with hypertension complicated by CHD, and collected related clinical data. They were divided into two groups according to different treatment plans, with 50 cases in each group: the control group was treated with bisoprolol while the combination group was treated with bisoprolol plus felodipine. The efficacy, adverse reactions, blood pressure ［including systolic blood pressure (SBP) and diastolic blood pressure (DBP)］ and heart rate levels, vascular endothelial function ［endothelin-1 (ET-1), vascular endothelial growth factor (VEGF) and nitric oxide (NO)］, inflammationrelated indicators ［lipoproteinassociated phospholipase A2 (LpPLA2), vascular cell adhesion molecule 1 (VCAM-1) and homocysteine (Hcy)］, and hemorheology ［hematocrit (HCT), platelet count (PLT), plasma viscosity (PV) and whole blood viscosity (WBV)］ were compared between the two groups. ResultsThe total effective rate of the combination group was higher than that of the control group (P<0.05). After treatment, SBP, DBP and heart rate in the combination group were all lower than those in the control group (P<0.05); VEGF and NO levels in the combination group were both higher than those in the control group, however HCT, PLT, PV, WBV, ET1, LpPLA2, VCAM1 and Hcy levels were all lower than those in the control group (P<005). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). ConclusionFelodipine combined with bisoprolol has significant efficacy for hypertension complicating CHD, which could relieve vascular endothelial injury, inhibit inflammatory response, improve hemorheology, and decrease blood pressure and heart rate. It serves as a safe and reliable medication therapy.