Value of detecting the glycosylated hemoglobin in early myocardial injury
LI Li1, YU Zhengqing1, HU Juan-yu2, CHEN Wei1, ZHAO Guang-chun1, ZHANG Si-jin1, QIAN Lei1
(1.Department of Clinical Laboratory, the People′s Hospital of Binhai, Binhai Jiangsu 224500; 2.Department of Clinical Laboratory, the Second People′s Hospital of Binhai, Binhai Jiangsu 224541, China)
Abstract:Objective: To explore the value of detection of glycosylated hemoglobin A1c(HbA1c) for the patients with early myocardial injury and investigate the correlation between HbA1c and highsensitivity cardiac troponin T(hscTnT). Methods: HbA1c was measured in 397 subjects with early myocardial injury, according to level of HbA1c, patients were divided into HbA1c<5.7% group, 5.7%-6.4% group and ≥6.5% group, at the same time , hscTnT were determined. Results: hscTnT level in HbA1c≥6.5% group was significantly higher than in HbA1c<5.7% group and 5.7%-6.4% group(P<0.05), HbA1c level was significantly positive correlated with hscTnT(r=0.952 9,P<0.05). Conclusion: Higher HbA1c is the independent risk factor of myocardial injury and HbA1c was positive correlated with hscTnT.
收稿日期: 2012-10-14
作者简介: 李礼(1977—),男,江苏滨海人,主管检验技师,硕士,主要从事临床生化检验工作。
引用本文:
李礼1, 于正清1, 胡娟玉2, 陈玮1, 赵广春1, 张似锦1, 钱雷1. 糖化血红蛋白检测在早期心肌损伤诊断中的价值[J]. 江苏大学学报:医学版, 2012, 22(6): 491-493.
LI Li1, YU Zhengqing1, HU Juan-yu2, CHEN Wei1, ZHAO Guang-chun1, ZHANG Si-jin1, QIAN Lei1. Value of detecting the glycosylated hemoglobin in early myocardial injury. Journal of Jiangsu University(Medicine Edition), 2012, 22(6): 491-493.
[1] 张振,李纪明,李新明.冠心病患者行OGTT试验及糖化血红蛋白检测的必要性研究[J]. 同济大学学报:医学版,2010,31(4):82-85.[2] 涂国华,姜旭淦,李礼,等.高效液相色谱测定糖化血红蛋白方法的建立与评价[J]. 江苏大学学报:医学版,2011,21(2): 147-150.[3] Thygesen K, Alpert JS, Jaffe AS, et, al. Third universal definition of myocardial infarction[J]. Nat Rev Cardiol,2012 ,9(11):620-633.[4] Reichlin T, Hochholzer W, Bassetti S,et al. Early diagnosis of myocardial infrction with sensitive cardiac troponin assays[J]. N Engl J Med, 2009,361(9):858-867. [5] Omland T, de Lemos JA,Sabatine MS, et al. A sensitive cardiac troponin T assay in stable coronary artery disease[J]. N Engl J Med, 2009,361(26):2538-2547.[6] Thevarajah M, Nadzimah MN, Chew YY. Interference of hemoglobinA1c (HbA1c) detection using ion-exchange high performance liquid chromatography (HPLC) method by clinically silent hemoglobin variant in university malaya medical centre (UMMC)-A case report[J]. Clin Biochem, 2009, 42(4/5):430-434.[7] International Expert Committee. International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes[J]. Diabetes Care,2009,32(7):1327-1334.[8] Atar D. New definition of myocardial infarction[J]. BMJ,2008,337:a3078.