Expression and clinical significance of miR-146a in human esophageal squamous cell carcinoma
JIN Li-Yan-1, Chen De-Yu-2, Mao Chao-Ming-2
1.School of Clinical Medicine, Jiangsu University, Zhenjiang Jiangsu 212001; 2. Institute of Oncology, the Affiliated Hospital of Jiangsu University, Zhenjiang Jiangsu 212001，China
Abstract：Objective: To investigate the expression of miR-146a in esophageal squamous cell carcinoma(ESCC) and analyze its correlation with clinicopathological features of ESCC. Methods: Stemloop RTPCR was used to detect the expression of miR-146a in 50 ESCC tissues and matched tumorfree tissues, and to analyze its correlation with clinicopathological features of ESCC. Results: The expression of miR-146a was significantly increased in ESCC tissues compared with the matched tumorfree tissues(Z=-3.162，P<0.01). Upregulation of miR-146a expression was correlated with differentiation degree, lymph node metastasis and clinical stage in ESCC(P<0.01). Conclusion: MiR-146a in ESCC tissues was significantly higher than that in matched tumorfree tissues, which may play a significant role in the occurrence and development of ESCC.
金丽艳1, 陈德玉2, 毛朝明2. miR-146a在食管鳞癌中的表达及意义[J]. 江苏大学学报:医学版, 2012, 22(5): 422-425.
JIN Li-Yan-1, Chen De-Yu-2, Mao Chao-Ming-2. Expression and clinical significance of miR-146a in human esophageal squamous cell carcinoma. Journal of Jiangsu University(Medicine Edition), 2012, 22(5): 422-425.
2012, Vol. 22 
