Abstract： Objective： To explore the correlation between hepatic steatosis index (HSI), fatty liver index (FLI) and nonalcoholic fatty liver disease (NAFLD) in type 2 diabetes mellitus(T2DM) population. Methods: A total of 566 subjects with T2DM were included. Clinical data were collected, and they were divided into non-NAFLD group and NAFLD group according to ultrasonography results. General clinical data, HSI and FLI were compared between the two groups. Logistic regression analysis was performed to explore the correlation between HSI，FLI and NAFLD in T2DM patients. The diagnostic value of HSI and FLI were evaluated according to receiver operating characteristic (ROC) curve. Results: The HSI (40.66±5.60 vs 34.58±3.99) and FLI (58.86±21.21 vs 28.96±20.18) in NAFLD group were significantly higher than those in non-NAFLD group (P<0.001). Correlation analysis showed that HSI and FLI were positively correlated with HOMA-IR, waist circumference, triglyceride and total cholesterol, but it was negatively correlated with high density lipoprotein cholesterol (HDL-C). Logistic regression analysis showed that after controlling for metabolic risk factors and hypoglycemic agents, HSI and FLI remained independent risk factors for NAFLD in T2DM patients. The sensitivity and specificity of HSI in diagnosing T2DM with NAFLD were 82.5% and 68.6% respectively. The sensitivity and specificity of FLI in diagnosing T2DM with NAFLD were 86.0% and 70.5% respectively. Conclusion: The HSI and FLI of T2DM patients are calculated according to the conventional biochemical indicators, which is simple and convenient, and may be used to diagnose NAFLD. ［Key words］nonalcoholic fatty liver disease; type 2 diabetes mellitus; hepatic steatosis index; fatty liver index
