Abstract：Objective: To investigate the change of serum asprosin level in patients with type 2 diabetes(T2DM) plus nonalcoholic fatty liver disease(NAFLD) and the influencing factors. Methods: Fifty T2DM cases without NAFLD(T2DM group) and 46 T2DM patients with NAFLD(T2DM plus NAFLD group) were selected. Serum asprosin was measured using ELISA method. Body mass index(BMI), waist hip rate(WHR), atherogenic index of plasma（AIP） and HOMAIR were calculated. Results: The asprosin levels were significantly higher in T2DM plus NAFLD group than that in T2DM group \[(1.85±0.79) vs (1.39±0.56) ng/mL, P<0.01\]. The correlation analysis revealed that serum asprosin levels were positively associated with the duration of T2DM,BMI,triglyceride and AIP. The duration of T2DM was the independent correlation factors for asprosin. With increasing of serum asprosin levels, the prevalence of NAFLD in Q1, Q2, Q3 gradually increased as 37.50％, 43.75％, 62.50％ respectively (P<0.05), the value of duration of T2DM, triglyceride and AIP increased gradually(P<0.05 or P<0.01). Conclusion: T2DM plus NAFLD group had significantly higher asprosin levels in comparison with T2DM group, indicating that asprosin may be involved in the development of T2DM plus NAFLD.
李昊翔, 徐梦娇, 袁婧, 丁艺, 杨玲, 王东， 赵丽， 袁国跃. 2型糖尿病合并非酒精性脂肪肝患者血清白脂素浓度变化及其影响因素[J]. 江苏大学学报:医学版, 2019, 29(01): 62-66.
LI Hao-xiang, XU Meng-jiao, YUAN Jing, DING Yi, YANG Ling, WANG Dong, ZHAO Li, YUAN Guo-yue. The change of serum asprosin level in patients with type 2 diabetes
plus nonalcoholic fatty liver disease and the influencing factors. Journal of Jiangsu University(Medicine Edition), 2019, 29(01): 62-66.
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2019, Vol. 29 
