Abstract：Objective: To investigate the peripheral blood of cyclophilin A levels in the patient with coronary heart disease (CHD) and its correlation with BNP、TnI. Method:A total of 127 patients who underwent coronary angiography were selected as research subjects. They were divided into three groups by coronary angiography: 41 cases of patients with stable angina as SAP; 43 cases of patients with acute coronary syndrome as ACS, including two groups, 20 cases of unstable angina as UAP, 23 cases of myocardial infarction as AMI; 43 cases of patients with non-coronary heart disease as control group. The blood of all patients were collected after in hospital, the AMI group was collected blood again after 1 week as recovery period. The cyclophilin A levels of all patients were measured with Elisa.Result:The cyclophilin A level in the ACS group was（24.2±2.7）ng/mL, and was higher than that in the SAP group (16.2±2.4)ng/mL and the control group (7.8±1.1)ng/mL（P<0.05）, but there was no significant difference between the AMI group (24.1±2.4)ng/mL and UAP group(24.5±3.1)ng/mL. The cyclophilin A level in the AMI group (after 1 week) was lower than that in the acute stage \[(17.9±3.0 )ng/mL vs（24.1±2.4）ng/mL）]（P<0.05）. In the ACS group, the BNP, TnI levels were higher than the control group; the LVEF was lower than the control group. The cyclophilin A levels had positive correlation with BNP, TnI（r=0.893，P<0.05；r=0.765，P<0.05）, and had negative correlation with LVEF（r=－0.528，P<0.05）. Conclusion:The cyclophilin A levels had close relation to the stability of coronary heart disease, and maybe could predict the occurrence of thrombotic events in patients with CHD. ［Key words］coronary heart disease； cyclophilin A； Btype natriuretic peptide； troponinI
2013, Vol. 23 
