Correlation between triglycerideglucose index and hyperuricemia in systemic lupus erythematosus patients
TAO Liangying1, SHU Ruilu 2, WU Yuting 1, WEN Lihui 3, ZHANG Huayong 1,3
(1. Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing Jiangsu 210008; 2. Department of Health Management Centre, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing Jiangsu 210008; 3. Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing Jiangsu 210008, China)
Abstract：Objective： To explore the correlation between triglyceride glucose (TyG) index and hyperuricemia (HUA) in patients with systemic lupus erythematosus (SLE). Methods： A retrospective cross-sectional study was conducted on 557 hospitalized SLE patients who were initially treated at Nanjing Drum Tower Hospital. Based on the presence or absence of hyperuricemia,they were divided into the HUA group and the SLE group, and a comparative analysis was performed on clinical data, laboratory indicators, and medication usage between the two groups. Logistic regression, restricted cubic spline, and subgroup analysis were used to evaluate the association between TyG index and hyperuricemia. Additionally, the values of various insulin resistance (IR) metabolic indices in predicting the risk of hyperuricemia in SLE patients were also compared using the area under the receiver operating characteristic curve (ROC). Results： In the HUA group, body mass index, systolic blood pressure, diastolic blood pressure, TyG index, 24 hour urine protein, creatinine, the prevalence of combined hyperlipidemia, and the use of tacrolimus were significantly higher compared to the SLE group. After controlling for confounding factors, binary logistic regression analysis revealed that the risk of developing hyperuricemia in the T3 (≥8.82) group, based on TyG index tertile grouping, was 2.900 times higher than that in the T1 (<8.31) group (95%CI: 1.565-5.371, P<0.05). There was a positive linear correlation between TyG index and the risk of hyperuricemia in SLE patients (P for trend<0.05, P for nonlinearity>0.05). Subgroup analysis further suggested gender and age differences in the association between TyG index and hyperuricemia. ROC curve analysis showed that the area under the curve for predicting the occurrence of hyperuricemia in SLE patients using TyG index,TG/HDL-C ratio, METS-IR, and TyG-BMI were 0.651, 0.656, 0.629, and 0.612, respectively. TyG index and TG/HDL-C had higher predictive values for SLE patients with hyperuricemia. Conclusion： Elevated TyG index is associated with an increased risk of hyperuricemia in SLE patients. As a low-cost and readily available indicator, TyG index may be used to predict the risk of hyperuricemia in patients with SLE.
［Key words］triglyceride glucose index; insulin resistance; hyperuricemia; systemic lupus erythematosus
