人体组分在系统性红斑狼疮患者营养评定中的应用

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摘要目的: 评估系统性红斑狼疮（SLE）患者的营养状况，分析SLE患者营养不良的危险因素。方法: 选取本院风湿免疫科收治的120例SLE患者，根据全球领导人营养不良倡议（GLIM）对SLE患者进行营养评定，分为非营养不良组（n=63）和营养不良组（n=57），对比分析两组患者的临床资料、实验室指标、人体组分数据和SLEDAI2000评分，Logistic回归分析预测SLE患者营养不良的危险因素。结果: ① SLE营养不良组患者的身高、体重、血红蛋白、血白蛋白、补体C3、补体C4水平均明显低于非营养不良组，差异具有统计学意义（P＜0.05）；SLE营养不良组的SLEDAI2000评分中位数为6.5, 明显高于非营养不良组（1.0，P＜0.001）。② SLE营养不良组的全身相位角、身体总水分、蛋白质量、骨骼肌量、身体细胞量、细胞内水分等人体成分明显低于非营养不良组（P＜0.05）。③ Logistic回归结果显示，全身相位角（OR：0.364，95% CI：0.180～0.737，P=0.005），蛋白质量（OR：0.195，95% CI：0.042～0.892，P=0.035）是SLE患者营养不良的独立影响因素。结论: 运用人体组分对SLE患者进行营养评定，可全面、准确地了解患者营养状况，为整体改善SLE患者临床预后提供依据。

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关键词 ：系统性红斑狼疮, 全球领导人营养不良倡议, 人体组分, 营养不良, 营养风险

Abstract：Objective： To evaluate the nutritional status of patients with systemic lupus erythematosus（SLE) by body composition assessment and to analyze the risk factors of malnutrition in SLE patients. Methods： A total of 120 patients with SLE were selected. According to the global leadership initiative on malnutrition（GLIM)， the SLE patients were divided into nondystrophic group （n=63) and dystrophic group（n=57). The clinical data, laboratory indicators, body composition data, and disease activity （SLEDAI2000 score) among the groups were compared and risk factors of malnutrition in SLE patients were analyzed by Logistic regression analysis.Results： ① The levels of height, body weight, hemoglobin, serum albumin, complement C3, and complement C4 in the SLE dystrophic group were statistically lower than those in the non-dystrophic group(P<0.05). The median of the SLEDAI2000 score of the SLE dystrophic group was 6.5, which was significantly higher than that of the non-dystrophic group(1.0， P<0.001). ② The wholebody phase angle, total body water, protein, skeletal muscle, body cell volume,intracellular fluid of the SLE dystrophic group were significantly lower than those in the non-dystrophic group （P<0.05).③ The Logistic regression analysis showed whole body phase angle （OR=0.364, 95% CI: 0.180-0.737, P=0.005）, protein(OR=0.195, 95% CI: 0.042-0.892, P=0.035) were independent influencing factors of malnutrition in SLE patients. Conclusion： Using body composition assessment to evaluate the nutritional status of SLE patients can comprehensively understand the nutritional status of patients， which has certain clinical significance for multidisciplinary management of SLE.

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收稿日期: 2022-01-12

基金资助:福建省自然科学基金面上项目（2019J0105）

通讯作者: 高飞（通讯作者），硕士生导师，E-mail：feifei7316749@aliyun.com

作者简介: 吴晨敏（1990—），女，硕士；

引用本文:

吴晨敏，严青，魏骐骄，等.. 人体组分在系统性红斑狼疮患者营养评定中的应用[J]. 江苏大学学报:医学版, 2022, 32(05): 427-432. WU Chenmin1， YAN Qing1， WEI Qijiao1， GAO Fei1,LYU Xinyang2. Application of body composition assessment in diagnosing malnutrition among systemic lupus erythematosus#br#. Journal of Jiangsu University(Medicine Edition), 2022, 32(05): 427-432.

链接本文:

http://zzs.ujs.edu.cn/xbyxb/CN/ 或 http://zzs.ujs.edu.cn/xbyxb/CN/Y2022/V32/I05/427

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