Abstract：Objective: To prepare a specific microcapsule with longacting mucosal adhesion and CT imaging used for the treatment of Helicobacter pylori infection. Methods: Catecholchitosan with mucoadhesive function was prepared by N(3dimethylaminopropyl)N′ethylcarbodiimide hydrochloride（EDC）catalyzed amide reaction. Then, catecholchitosan coating microcapsule with barium sulfate was obtained (CatC/A@BS MCs) by onestep electrostatic spraying and polyelectrolyte selfassembly method. Mice were continuously intragastrically administered for 10 days, and their body weight changes and rapid urease test intensity were evaluated. Results: CatC/A@BS MCs with uniform morphology and particle size about 500 μm were successfully prepared. CatC/A@BS MCs have good CT imaging capabilities and can effectively retention in the mice digestive tract for up to 48 hours. In vivo experiments verified that CatC/A@BS MCs effectively increased the clearance rate of Helicobacter pylori infection by amoxicilin. Conclusion: The successful constructed mucosal adhesion and CT imaging dualfunction microcapsules significantly improved the removal of Helicobacter pylori infection by amoxicillin.
收稿日期: 2019-03-18
基金资助:
江苏省“六大人才高峰”高层次人才项目（2014-WSN-281）
作者简介: 吴云超（1994—），女，硕士研究生
引用本文:
吴云超， 赵璐璐， 蔡茸， 徐丽霞， 龚爱华， 张苗苗， 杜凤移. 长效黏膜黏附型微胶囊的构建及在幽门螺杆菌感染小鼠中的应用[J]. 江苏大学学报:医学版, 2019, 29(05): 394-397,404.
WU Yun-chao, ZHAO Lu-lu, CAI Rong, XU Li-xia, GONG Ai-hua, ZHANG Miao-miao, DU Feng-yi. Construction of long-lasting gastric mucoadhesive microcapsules applied to mice infected with Helicobacter pylori. Journal of Jiangsu University(Medicine Edition), 2019, 29(05): 394-397,404.
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2019, Vol. 29 
