Betatrophin基因多态性与2型糖尿病的相关性

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摘要目的: 探讨Betatrophin基因rs2278426多态性与2型糖尿病（T2DM）的相关性。方法: 分别选取T2DM患者(T2DM组)和健康者(对照组)各200例，采用聚合酶链式反应—限制性片段长度多态性(PCRRFLP)技术，对Betatrophin基因rs2278426多态性进行检测。结果： T2DM组Betatrophin基因rs2278426位点C/T+T/T基因型及T等位基因的频率明显高于对照组（P<0.05）。C/T+T/T基因型携带者空腹血糖及120 min OGTT血糖(2hPG)明显高于C/C基因型携带者（P<0.05）。Logistic回归分析显示，Betatrophin基因rs2278426 T等位基因相对于C等位基因，增加T2DM的发病风险。结论： Betatrophin基因rs2278426多态性可能与T2DM的发生有关，T等位基因可能增加T2DM的发病风险。

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关键词 ： Betatrophin, 单核苷酸多态性, 2型糖尿病

Abstract：Objective: To investigate the association between rs2278426 polymorphism of betatrophin gene and type 2 diabetic mellitus (T2DM). Methods: A total of 200 subjects with T2DM (T2DM group) and 200 healthy controls (control group) were enrolled in this study. The genotype of betatrophin SNP rs2278426 was detected by the polymerase chain reactionrestricted fragment length polymorphism (PCRRFLP). Results: The frequency of C/T+T/T genotype and T allele of rs2268388 were significantly higher in T2DM group than those in control group(P<0.05).Fasting plasma glucose and 120 min OGTT glucose (2hPG) in carriers with C/T+T/T genotype were higher than those with CC genotype. Logistic regression analysis showed that the risk of T2DM increased in betatrophin rs2278426 T allele carriers compared with those with C allele. Conclusion: The betatrophin rs2278426 gene polymorphism may be associated with T2DM.The T allele may increase the risk of T2DM.

基金资助:国家自然科学基金资助项目（81570721，81370965）；江苏省自然科学基金资助项目（BK20151331）；江苏省重点研发计划项目（BE2018692）；江苏省高层次卫生人才“六个一工程”项目（LGY2016053）；江苏省“六大人才高峰”第十二批高层次人才项目（2015-WSN-006）

通讯作者: 袁国跃（通讯作者），主任医师，教授，博士生导师，E-mail: yuanguoyue@ hotmail.com

作者简介: 丁艺(1993—)，女，硕士研究生

引用本文:

丁艺，李昊翔，徐梦娇，袁婧，赵丽，王东，杨玲，袁国跃. Betatrophin基因多态性与2型糖尿病的相关性[J]. 江苏大学学报:医学版, 2019, 29(01): 72-76. DING Yi， LI Hao-xiang， XU Meng-jiao， YUAN Jing， ZHAO Li， WANG Dong， YANG Ling， YUAN Guo-yue. Association between the polymorphism of betatrophin gene and type 2 diabetes mellitus. Journal of Jiangsu University(Medicine Edition), 2019, 29(01): 72-76.

链接本文:

http://zzs.ujs.edu.cn/xbyxb/CN/ 或 http://zzs.ujs.edu.cn/xbyxb/CN/Y2019/V29/I01/72

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