2型糖尿病患者颈动脉内中膜厚度与低度白蛋白尿的相关性

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摘要目的: 探讨2型糖尿病（type 2 diabetes mellitus,T2DM）患者颈动脉内中膜厚度（carotid intimamadia thickness,CIMT）与低度白蛋白尿的相关性。方法: 选择T2DM患者460例，检测CIMT和尿白蛋白/肌酐比值（urinary albumintocreatinine ratio，UACR）。根据UACR四分位切点将全部患者分为4组，分别为0＜Q1＜7.06 mg/g（n=112），7.06≤Q2＜8.91 mg/g（n=118），8.91≤Q3＜12.10 mg/g（n=115），12.10≤Q4＜30.0 mg/g（n=115）。收集4组患者的一般资料，采用Logistic回归分析CIMT和UACR的相关性。结果： Q1-Q4组CIMT增厚的发生率分别为30.36%、38.14%、45.22%、53.91%，且CIMT与UACR呈正相关（r=0.300，P<0.01）。Logistic回归分析显示UACR与CIMT增厚发生率相关(OR：1.166，95%CI：1.080～1.259，P<0.01)。结论：随着UACR升高，CIMT增加。UACR是T2DM患者CIMT增厚的危险因素。

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关键词 ：颈动脉内中膜厚度, 2型糖尿病, 低度白蛋白尿, 危险因素

Abstract：Objective: To investigate the relationship between carotid intimamedia thickness(CIMT) and lowgrade albuminuria in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 460 inpatients with T2DM were recruited. The CIMT and urinary albumintocreatinine ratio(UACR) were measured. Based on the quartile of UACR, all patients were divided into four groups: 0＜Q1＜7.06 mg/g(n=112),7.06≤Q2＜8.91 mg/g(n=118),8.91≤Q3＜12.10 mg/g(n=115),12.10≤Q4＜30.0 mg/g(n=115).Baseline data and clinical data of each patient was collected. The relationship between CIMT and UACR were tested with Logistic regression. Results: The prevalence of CIMT was 30.36% in Q1, 38.14% in Q2, 45.22% in Q3 and 53.91% in Q4, respectively. And CIMT was positively correlated with UACR（r=0.300,P<0.01）.Logistic regression revealed that UACR had correlation with elevated CIMT(OR:1.166, 95%CI: 1.080-1.259, P<0.01). Conclusion: The prevalence of CIMT in T2DM patients increased with the rise of UACR. UACR is risk factor for T2DM patients with elevated CIMT.

收稿日期: 2017-09-26

通讯作者: 宋光耀（通讯作者），主任医师，E-mail:sguangyao2@163.com

引用本文:

商书霞1，李晓静1，宋光耀2，牛耘1，段丽君1，郭洪涛1. 2型糖尿病患者颈动脉内中膜厚度与低度白蛋白尿的相关性[J]. 江苏大学学报:医学版, 2018, 28(02): 154-157,168. SHANG Shu-xia1, LI Xiao-jing1, SONG Guang-yao2, NIU Yun1， DUAN Li-jun1, GUO Hong-tao1. Association of carotid intima-media thickness and low-grade albuminuria in patients with type 2 diabetes. Journal of Jiangsu University(Medicine Edition), 2018, 28(02): 154-157,168.

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http://zzs.ujs.edu.cn/xbyxb/CN/ 或 http://zzs.ujs.edu.cn/xbyxb/CN/Y2018/V28/I02/154

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