Abstract：Objective: To analyse association between intraoperative hypotension and outcome after severe traumatic brain injury. Methods: A retrospective analysis was performed of severe TBI patients and recorded next indexes as independent variables: gender, age, diagnosis, preoperative GCS score, pupil, blood pressure, mannitol, intraoperative anesthesia induced hyperventilation, intraoperative hypotension, controlling boost gradient, gradient lower intracranial pressure. Prognostic indicators, including inhospital mortality and days during intensive care unit (ICU), Glasgow outcome score (GOS) at discharge, were recorded as the dependent variables. The differences between each variable was analysed by the binary Logistic regression. Results: There were 41 cases (23.2%) died within one month after surgery, 134 patients survived more than one month. The survival patients′ discharge GOS score 1-3 were 44 cases, and 4-5 90 cases. Intraoperative hypotension was associated with postoperative 1 month mortality and survival ICU stay, but no with hospital discharges GOS. However, with other factors, such as the pupil, the preoperative GCS, intraoperative hypotension did not reach statistical difference, which indicated intraoperative hypotension was not independent relevant factors of postoperative 1 month mortality and ICU stay. Conclusions: Intraoperative hypotension was associated with the mortality in patients with severe traumatic brain injury, but not independent factor and influenced by the severity of the disease. To prevent intraoperative hypotension can improve the prognosis of patients with severe traumatic brain injury.
王云环1， 徐敏2， 陈淑华3， 陆晓峰2，. 重型颅脑损伤患者术中低血压对预后的影响[J]. 江苏大学学报:医学版, 2013, 23(5): 423-427.
WANG Yun-huan1, XU Min2, CHEN Shu-hua3, LU Xiao-feng2, . Association between intraoperative hypotension and outcome after severe traumatic brain injury. Journal of Jiangsu University(Medicine Edition), 2013, 23(5): 423-427.
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2013, Vol. 23 
