Abstract:Objective: To evaluate the value of inflammatory factor score in prognosis of advanced nonsmall cell lung cancer(NSCLC). Methods: The clinical data of 156 patients with advanced NSCLC were collected. The modified Glasgow prognostic score(mGPS), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were tested. The mGPS was divided into 0, 1, 2 groups based on Creactive protein and albumin. The NLR and PLR were divided into low score groups and high score groups with median as the optimal cutoff value, respectively. The relationship between the inflammatory index and the clinical features, chemotherapy efficacy and progressionfree survival(PFS) were analyzed. The prognostic factors of age, gender, tumor markers, pathological types, distant metastasis, mGPS, NLR, PLR and white blood cells were evaluated by univariate and multivariate regression analysis. Results: The objective response rate(ORR) of mGPS 0 group was higher than that of mGPS 1 group and mGPS 2 group(P<0.05). The ORR of low NLR group was higher than that of high NLR group(P<0.05). There was no statistical difference between PLR groups(P>0.05). The disease control rate of mGPS 0 group was higher than that of mGPS 1 group and mGPS 2 group, low NLR group was higher than that of high NLR group, and low PLR group was higher than that of high PLR group(P<0.05). Between the three groups of mGPS0, 1 and 2, the PFS was longer in the low score group than that in the high score group (P<0.05). PFS of low NLR group and low PLR group were longer than those of high NLR group and high PLR group, respectively(P<0.05). The number of pleural metastases was increased in high NLR and PLR groups(P<0.05). Cox multivariate analysis showed mGPS was an independent risk prognostic factor for NSCLC(HR=1.962, 95%CI:1.417~2.716, P<0.05). Conclusion: The mGPS, NLR and PLR were associated with prognosis of NSCLC patients; and mGPS is an independent risk factor for PFS in advanced NSCLC patients.
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