Micronucleus test of NaCl extrafine powder in BALB／c mice
WU Zhan-ao1, FAN Li-juan2, XU Hua-jun3, DUAN Li-rong4
(1.Department of Stomatology, the No.359 Hospital of Chinese PLA, Zhenjiang Jiangsu 212001; 2.Department of Respiratory Medicine, the No.359 Hospital of Chinese PLA, Zhenjiang Jiangsu 212001; 3.Zhenjiang Salt Chemical Company，Zhenjiang Jiangsu 212001; 4.School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang Jiangsu 212013， China)
Abstract：Objective: Observing the toxic reaction and calculating the micronucleus rate of BALB／c mice administrated by different doses of NaCl extrafine powder to provide a reference for further mutagenesis studies. Methods: The experimental animals were randomly divided into five groups: negative control group,low-dose NaCl extrafine powder group,middle-dose group, high-dose group,and positive control group. Ten animals were in each group. By continous administration, the general toxicity, body weight growth,and bone marrow cell micronucleus in mice were observed during the experimental period. Results: No abnormal reactions in animal mind and appearance were observed.The growth of body weight in high-dose group decreased after 3rd day after administration, while the low-dose NaCl extrafine powder group and middle-dose group showed normal body weight. NaCl extrafine powder(pM2.5-10)within the dose of 5.0, 2.5, 1.25 mg／kg did not significantly affect the mouse bone marrow micronucleus rate. Conclusion: NaCl extrafine powder had no significant mutagenicity on mouse bone marrow cells.
收稿日期: 2012-12-02
基金资助:
中国盐业总公司科技发展计划资助项目（中盐办发制盐［2009］13号）
作者简介: 吴占敖（1966—），男，江苏宜兴人，副主任医师，主要从事口腔等疾病的临床诊治研究。
引用本文:
吴占敖1, 范利娟2, 许华君3, 端礼荣4. 超细氯化钠粉的BALB／C小鼠骨髓微核实验[J]. 江苏大学学报:医学版, 2013, 23(1): 9-12.
WU Zhan-ao1, FAN Li-juan2, XU Hua-jun3, DUAN Li-rong4. Micronucleus test of NaCl extrafine powder in BALB／c mice. Journal of Jiangsu University(Medicine Edition), 2013, 23(1): 9-12.
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2013, Vol. 23 
