Abstract：Objective: The study was to investigate the expression and significance of TRIM25 and PTEN in myeloidderived suppressor cells (MDSCs) from tumor tissue of tumor-bearing (TB) mice. Methods: CT26 colon cancer tumor-bearing mice models were established. The expressions of TRIM25 and PTEN were detected in MDSCs derived from tumor tissue of TB mice and spleen of wild-type (WT) mice with qRTPCR method. Results: In CT26 cells bearing mice models, the expression level of TRIM25 in tumor tissue-derived MDSCs of TB mice was significantly higher than that from spleen of WT mice(P<0.001). Inversely, compared to WT mice, PTEN expression was obviously down-regulated in MDSCs isolated from tumor tissue of TB mice (P<0.001). Conclusion: TRIM25 expression level was up-regulated, while the expression of PTEN was suppressed in MDSCs from tumor tissue of TB mice. They both may participate in the regulation of MDSCs.
收稿日期: 2019-03-20
基金资助:
江苏省科技计划项目临床医学专项（BL2014065）; 江苏大学大学生科研立项项目（15A332）
通讯作者:
王胜军（通讯作者），教授，博士生导师，E-mail:sjwjsu@aliyun.com
作者简介: 宋格（1991—），女，硕士研究生
引用本文:
宋格， 赵耀， 陆薇， 王胜军. 荷瘤小鼠MDSCs中TRIM25和PTEN的表达[J]. 江苏大学学报:医学版, 2019, 29(04): 333-338.
SONG Ge, ZHAO Yao, LU Wei, WANG Sheng-jun. Expression of TRIM25 and PTEN in MDSCs of tumor-bearing mice. Journal of Jiangsu University(Medicine Edition), 2019, 29(04): 333-338.
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2019, Vol. 29 
