Abstract：Objective: To investigate protective effect of lycopene on liver fibrosis in mice induced by concanavalin A (Con A). Methods: Twentyfour mice were equally randomized into 3 groups: control group, model group and prevention group. The mice in model group was received intraperitoneal injection of CoA(20 mg/kg),one time per week, while control group received normal saline, prevention group was received intragastric administration of lycopene, one time per day, for 8 weeks. Mice blood were collected to test the indices of hepatic fibrosis. Grade of hepatic fibrosis were evaluated according to the semi-quantitative scoring system (SSS). Western blotting was used to test the expression of α-smooth muscle actin(α-SMA), Smad3 protein(Smad3) and transforming growth factor-β1 (TGF-β1). Results: Compared with the control group,the model group showed higher serum levels of hyaluronic acid (HA), laminin (LN), procollagen type Ⅲ(PCⅢ) , SSS score, malonaldehyde level, the expression of α-SMA, TGF-β1 and Smad3, lower superoxide dismutase (SOD) (both P<0.01); compared with the model group, the prevention group showed lower serum levels of HA, LN, PCⅢ, SSS score, malonaldehyde level, the expression of α-SMA, TGF-β1 and Smad3, higher levels of SOD (both P<0.01). Conclusion: Lycopene could sharply decrease the harm of peroxidation, protect the liver cells, reduce the collagen production and restrain the expression of the important factor of α-SMA, Smad3, TGF-β1 which lead to liver fibrosis, so that lycopene had the notable alleviate effect on liver fibrosis induced by ConA.
收稿日期: 2014-05-01
作者简介: 赵凯(1974—)，男，江苏金坛人，副主任医师，主要从事肝脏疾病的基础和临床研究。
引用本文:
赵凯. 番茄红素对小鼠肝纤维化的保护作用[J]. 江苏大学学报:医学版, 2014, 24(04): 290-293.
ZHAO Kai. Protective effect of lycopene on hepatic fibrosis in mice. Journal of Jiangsu University(Medicine Edition), 2014, 24(04): 290-293.
2014, Vol. 24 
