ALDH2和ADH1B基因多态性与食管癌淋巴结转移的相关性

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摘要目的：研究中国汉族人群中乙醛脱氢酶2（aldehyde dehydrogenase 2，ALDH2）和乙醇脱氢酶1B（alcohol dehydrogenase 1B,ADH1B）基因多态性与食管癌淋巴结转移风险性的关系。方法：采用基质辅助激光解吸电离飞行时间质谱(matrixassisted laser desorption/ ionization time of flight mass spectrometry, MALDITOF MS)技术分析85例有淋巴结转移的食管癌和270例无淋巴结转移的食管癌标本ALDH2 rs671和ADH1B rs1229984基因多态性，计算各种基因型与食管癌淋巴结转移的相对风险度及其95%可信区间。结果： ALDH2 rs671 G>A3种多态基因型GG,GA,AA在食管癌淋巴结转移组和无淋巴结转移组的频率分别为58.8%(GG),38.8%(GA),2.4%(AA)和59.3%(GG),37.4%(GA),3.3%(AA)(χ2 =0.237, P=0.888)；以ALDH2 rs671 GG基因型作参照，ALDH2 rs671 AA基因型食管癌淋巴结转移发生的风险降低（调整年龄、性别、吸烟及饮酒状态OR=0.70, 95% CI=0.14 ~3.45）, 但相关性未达到明显统计学意义。ADH1B rs1229984 A>G3种多态基因型AA, AG, GG在食管癌淋巴结转移组和无淋巴结转移组的频率分别为38.8%(AA), 50.6%(AG), 10.6%(GG)和42.8%(AA), 41.6%(AG), 15.6%(GG)(χ2=2.553, P=0.279)，以ADH1B rs1229984 AA基因型作参照，ADH1B rs1229984 GG基因型食管癌淋巴结转移发生的风险降低（调整年龄、性别、吸烟及饮酒状态OR=0.66, 95% CI=0.29 ~1.53), 但相关性未达到明显统计学意义。结论： ALDH2 rs671 G>A和ADH1B rs1229984 A>G基因多态性可能与食管癌淋巴结转移的风险无明显相关，需进一步研究证实。

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	方娜
	钟锡明
	范钰

关键词 ：乙醛脱氢酶2, 乙醇脱氢酶1B, 食管癌, 淋巴结转移, 单核苷酸多态性

Abstract：Objective: To investigate the relationship between ADH1B rs1229984 and ALDH2 rs671 polymorphisms and the susceptibility to lymphatic metastasis in esophageal cancer in a Chinese Han population. Methods: Genotypes were determined by matrixassisted laser desorption/ionizationtime of flight mass spectrometry(MALDITOF MS) method in 85 esophageal cancer lymphatic metastasis positive patients and 270 lymphatic metastasis negative patients. The associations between ALDH2 rs671 G>A and ADH1B rs1229984 A>G genotypes and the risk of esophageal cancer lymphatic metastasis were estimated by computing the odds ratio(OR) and their 95% confidence interval(CI). Results: The ALDH2 rs671 G>A genotype frequencies were 58.8%(GG), 38.8%(GA), 2.4%(AA) in the lymphatic positive group and 59.3%(GG), 37.4%(GA), 3.3%(AA) in the lymphatic negative group, respectively(χ² =0.237, P=0.888)； logistic regression analyses revealed that ALDH2 rs671 AA genotype could reduce the risk of lymphatic metastasis(adjusted OR=0.70, 95% CI=0.14-3.45) compared with ALDH2 rs671 GG genotype, but the difference was not statistically significant. The ADH1B rs1229984 A>G genotype frequencies were 38.8%(AA), 50.6%(AG), 10.6%(GG) in the lymphatic positive group and 42.8%(AA), 41.6%(AG), 15.6%(GG) in the lymphatic negative group, respectively(χ² =2.553, P=0.279); logistic regression analyses revealed that ADH1B rs1229984 GG genotype could reduce the risk of lymphatic metastasis(adjusted OR=0.66, 95% CI=0.29-1.53) compared with ADH1B rs1229984 AA genotype, but the difference was not statistically significant. Conclusion: ALDH2 rs671 G>A and ADH1B rs1229984 A>G polymorphisms might not be associated with the risk of esophageal cancer lymph node metastasis， and awaits further investigation.

收稿日期: 2012-05-13

作者简介: 方娜（1979—），女，江苏丹阳人，主治医师，硕士，主要从事肿瘤化疗临床研究。

引用本文:

方娜, 钟锡明, 范钰. ALDH2和ADH1B基因多态性与食管癌淋巴结转移的相关性[J]. 江苏大学学报:医学版, 2012, 22(5): 414-417. FANG Na, Zhong Xi-Ming, Fan Yu. Relationship between ALDH2, ADH1B variant alleles and risk of esophageal cancer lymphatic metastasis. Journal of Jiangsu University(Medicine Edition), 2012, 22(5): 414-417.

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http://zzs.ujs.edu.cn/xbyxb/CN/ 或 http://zzs.ujs.edu.cn/xbyxb/CN/Y2012/V22/I5/414