Abstract:Atrial fibrillation(AF) is the most common sustained arrhythmia which contributes to the increasing mortality risk in clinical practice. Gastroesophageal reflux disease(GERD) is commonly seen in the department of Gastroenterology. It refers to discomfortable symptoms and(or) complications caused by the reflux of gastric contents into esophagus. It was reported that gastroesophageal reflux may give rise to AF. Inflammation, vagal stimulation and chronic atrial ischemia may be important potential mechanisms; inflammatory responses and autonomic nervous dysfunction take part in the onset and development of AF and GERD. Based on correlative domestic and foreign references, this paper reviews the relationship between AF and GERD, and its possible mechanisms.
崔丽, 李广平, 刘彤. 胃食管反流病与心房颤动[J]. 实用心电学杂志, 2016, 25(4): 294-297.
CUI Li, LI Guang-Ping, LIU Tong. Relationship between gastroesophageal reflux disease and atrial fibrillation. JOURNAL OF PRACTICAL ELECTROCARDIOLOGY, 2016, 25(4): 294-297.
[1] Vakil N. Disease definition, clinical manifestations, epidemiology and natural history of GERD[J]. Best Pract Res Clin Gastroenterol, 2010, 24(6):759-764.[2] NessJensen E, Lindam A, Lagergren J, et al. Changes in prevalence, incidence and spontaneous loss of gastrooesophagealreflux symptoms: a prospective populationbased cohort study, the HUNT study[J]. Gut, 2012, 61(10):1390-1397.[3] Parasa S, Sharma P. Complications of gastrooesophageal reflux disease[J]. Best Pract Res Clin Gastroenterol, 2013, 27(3):433-442.[4] 周自强,胡大一,陈捷,等.中国心房颤动现状的流行病学研究[J].中华内科杂志,2004,43(7):491-494.[5] 姚光辉. 62例高龄病例心房颤动的临床分析[J]. 江苏实用心电学杂志,2012,21,(1):13-15.[6] Kunz JS, Hemann B, Edwin Atwood J, et al. Is there a link between gastroesophageal reflux disease and atrial fibrillation?[J]. Clin Cardiol, 2009, 32(10):584-587.[7] Huang CC, Chan WL, Luo JC, et al. Gastroesophageal reflux disease and atrial fibrillation: a nationwide populationbased study[J]. PLoS One, 2012, 7(10):e47575.[8] Bunch TJ, Packer DL, Jahangir A, et al. Longterm risk of atrial fibrillation with symptomatic gastroesophageal reflux disease and esophagitis[J]. Am J Cardiol, 2008, 102(9):1207-1211.[9] Kubota S, Nakaji G, Shimazu H, et al. Further assessment of atrial fibrillation as a risk factor for gastroesophageal reflux disease: a multicenter questionnaire survey[J]. Intern Med, 2013,52(21):2401-2407.[10] Shimazu H, Nakaji G, Fukata M, et al. Relationship between atrial fibrillation and gastroesophageal reflux disease: a multicenter questionnaire survey[J]. Cardiology, 2011, 119(4):217-23.[11] Kusano M, Hosaka H, Kawada A, et al. Development and evaluation of a modified Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease to distinguish functional dyspepsia from nonerosive reflux disease[J]. J Gastroenterol Hepatol,2012, 27(7):1187-1191.[12] Weigl M, Gschwantler M, Gatterer E, et al. Reflux esophagitis in the pathogenesis of paroxysmal atrial fibrillation: results of a pilot study[J]. South Med J, 2003, 96(11):1128-1132.[13] Reddy YM, Singh D, Nagarajan D, et al. Atrial fibrillation ablation in patients with gastroesophageal reflux disease or irritable bowel syndromethe heart to gut connection[J]. J Interv Card Electrophysiol, 2013, 37(3): 259-265.[14] Lioni L, Letsas KP, Efremidis M, et al. Gastroesophageal reflux disease is a predictor of atrial fibrillation recurrence following left atrial ablation[J]. Int J Cardiol, 2015,183:211-213.[15]Tougas G, Spaziani R, Hollerbach S, et al. Cardiac autonomic function and oesophageal acid sensitivity in patients with noncardiac chest pain[J]. Gut, 2001, 49(5):706-712.[16] Ravelli F, Allessie M. Effects of atrial dilatation on refractory period and vulnerability to atrial fibrillation in the isolated Langendorffperfused rabbit heart [J]. Circulation, 1997, 96(5): 1686-1695.[17] 黄赟,潘闽. 心房颤动与炎症关系的研究进展[J]. 江苏实用心电学杂志, 2014, 23(3):204-207.[18] Li J, Solus J, Chen Q, et al. Role of inflammation and oxidative stress in atrial fibrillation[J]. Heart Rhythm, 2010, 7(4):438-444. [19] Gerson LB, Friday K, Triadafilopoulos G. Potential relationship between gastroesophageal reflux disease and atrial arrhythmias[J]. J Clin Gastroenterol, 2006, 40(9): 828-832.[20] Yoshida N, Uchiyama K, Kuroda M, et al. Interleukin8 expression in the esophageal mucosa of patients with gastroesophageal reflux disease[J]. Scand J Gastroenterol, 2004, 39(9):816-822.[21] Rieder F, Cheng L, Harnett KM, et al. Gastroesophageal reflux diseaseassociated esophagitis induces endogenous cytokine production leading to motor abnormalities[J]. Gastroenterology, 2007,132(1):154-165. [22] Liu T, Li G. Is atrial fibrillation an inflammatory disease? [J]. Med Hypotheses, 2005, 64(6): 1237-1238.[23] Liu T, Li G, Li L, et al. Association between Creactive protein and recurrence of atrial fibrillation after successful electrical cardioversion: a metaanalysis[J]. J Am Coll Cardiol, 2007, 49(15):1642-1648. [24] Chauhan A, Mullins PA, Taylor G, et al. Cardioesophageal reflex: a mechanism for “linked angina” in patients with angiographically proven coronary artery disease[J]. J Am Coll Cardiol,1996, 27(7):1621-1628.