Abstract:Objective To observe the correlation between hyperuricemia and cardiac autonomic nervous function in patients with coronary disease. Methods Clinical data of 168 patients diagnosed with coronary disease were analyzed. Among those cases, there were 67 complicated with hyperuricemia(group HUA+) with 39 males and 28 females at an average age of (61.16±6.66) years old; there were 101 complicated without hyperuricemia(group HUA-) with 66 males and 35 females at an average age of (61.96±5.51) years old. Each index of heart rate variability(HRV) in the two groups was observed. Results The HRV indices of SDNN, SDANN index, SDNN index and rMSSD in group HUA+ were significantly lower than those in group HUA-(P<0.05). Conclusion This paper reveals that hyperuricemia can aggravate cardiac autonomic nervous dysfunction in patients with coronary disease.
朱珲莹, 叶焕文, 温建炫. 冠心病合并高尿酸血症患者心脏自主神经功能研究[J]. 实用心电学杂志, 2016, 25(2): 112-115.
ZHU Hui-Ying, YE Huan-Wen, WEN Jian-Xuan. Study on cardiac autonomic nervous function of patients with coronary disease complicating hyperuricemia. JOURNAL OF PRACTICAL ELECTROCARDIOLOGY, 2016, 25(2): 112-115.
[1] 符彬, 陈新. 高尿酸血症与心血管疾病关系的Meta分析[J]. 中国全科医学, 2007, 10(6):451-453. [2] Deschamps A, Denault A. Autonomic nervous system and cardiovascular disease[J]. Semin Cardiothorac Vasc Anesth, 2009, 13(2):99-105.[3] Feig DI, Kang DH, Johnson RJ. Uric acid and cardiovascular risk[J]. N Engl J Med, 2008, 359(17):1811-1821.[4] 吕江峰, 徐凤玲, 刘璐. 高尿酸血症与冠状动脉疾病及其严重程度的相关性研究[J]. 中国循环杂志,2014, 29(2):103-106. [5] 高鹏芝,高旭,魏冬,等.高尿酸血症与冠心病的关系[J].山东医药,2013,53(29):13-15.[6] Zapolski T, Waciński P, Kondracki B, et al. Uric acid as a link between renal dysfunction and both proinflammatory and prothrombotic state in patients with metabolic syndrome and coronary artery disease[J]. KardiolPol, 2011, 69(4):319-326.[7] 洪冰, 王连环, 林祥灿. 高尿酸血症与心血管疾病关系的研究进展[J]. 山东医药, 2013, 53(27):98-100.[8] 刘涛, 顾晔, 李论, 等. 冠状动脉病变程度与自主神经功能的相关性[J]. 上海医学, 2013, 36(7):902-904.[9] 朱俏萍, 张萍, 刘伊丽, 等. 极化液联合美托洛尔对急性心肌梗死患者自主神经失衡的保护作用研究[J]. 解放军医学杂志, 2009, 34(1):116-117.[10] Piccirillo G, Fimognari FL, Santagada E, et al. Power spectral analysis of heart rate in elderly hypertensive subjects with or without silent coronary disease[J]. Angiology, 1996, 47(1):15-22.