Abstract：Objective To observe the changes of heart rate variability(HRV) of patients with type 2 diabetes mellitus(T2DM) before and after treatment.MethodsDiabetes mellitus group enrolled 48 cases of T2DM patients and another 50 healthy volunteers participated in the control group. Before and after the treatment of T2DM patients, the changes of their HRV time domain indexes SDNN,SDANN,rMSSD and PNN50, and HRV frequency domain indexes LF,HF,LF/HF,VLF were observed and compared with those of control group.ResultsBefore the treatment, the HRV time domain and frequency domain indexes of diabetes mellitus group were all lower than those of control group(P＜0.05). Compared with situations before the treatment, the HRV time domain indexes of diabetes mellitus group such as SDNN, SDANN, rMSSD and PNN50 all improved in some extent after the treatment(P＜0.05)，so did the HRV frequency domain indexes of LF, HF and VLF(P＜0.05).ConclusionT2DM patients are usually found abnormity in regulation function of cardiac autonomic nerve, mainly vagus lesions. After proper treament, the regulation function of autonomic nerve could be recovered in some extent.
2014, Vol. 23 
