Abstract:Radiation-induced heart disease(RIHD) proves to be one of the common adverse reactions due to radiotherapy for thoracic neoplasms. It can significantly increase the risk of coronary artery disease, pericardial disease, valvular heart disease and sudden death. It has been found by research that serum cardiac troponin I (cTnI) and heart rate variability(HRV) could be utilized in the evaluation of RIHD, but difficult to be used in early diagnosis.Recent studies have shown the important relationship between the incidence of RIHD and the volume and dose of heart irradiated.Therefore we intend to test serum cTnI, HRV and dose-volume histogram jointly to predict the disease, and explore effective biochemical and physical indicators furtherly for early prediction of heart injury due to radiotherapy for thoracic neoplasms, in order to provide important reference for clinical treatment.
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