Abstract：Objective To investigate the changes of serum creatine kinase isoenzyme (CK-MB), homocysteine (Hcy) and B-type natriuretic peptide (BNP) levels in patients with acute myocardial infarction (AMI), and to analyze their correlation with the severity of the disease and their predictive value on major adverse cardiovascular events (MACEs). Methods A total of 102 patients with AMI were selected as the research group while another 102 healthy physical examinees during the same period were selected as the control group. The changes of serum CK-MB, Hcy and BNP levels were compared separately between different groups and among the enrolled patients with different numbers of coronary lesions. Spearman and Pearson correlation analysis was utilized to explore the correlation between serum indicators and the number of coronary lesions or Gensini score. Patients in the research group were treated by percutaneous coronary intervention (PCI). They were divided into subgroups with or without MACEs according to the presence or absence of MACEs 6 months after the surgery. The serum CK-MB, Hcy and BNP levels were analyzed in each group before PCI and one month after the surgery. The predictive value of each serum indicator level one month after operation on MACEs was analyzed by using ROC curve. ResultsThe serum levels of CK-MB, Hcy and BNP in the research group were higher than those in the control group (P<0.01); serum CK-MB, Hcy and BNP levels were positively correlated with the number of coronary lesions and Gensini score (P<0.05). One month after surgery, the serum CK-MB, Hcy and BNP levels of the patients with MACEs were higher than those of the patients without MACEs (P<0.05). The AUC value of the combination of serum CK-MB, Hcy and BNP levels one month after surgery for MACEs was 0.943, which was higher than the AUC value of single indicator (0.769, 0.847 and 0.794, respectively;P<0.05). Conclusion The serum levels of CK-MB, Hcy and BNP in AMI patients are elevated, which are closely related to the severity of the disease. The combined detection of the above serum indicators has certain predictive value for the occurrence of MACEs.
