Relationship between QRS duration of ECG and ventricular electrical mechanical asynchrony in patients with chronic heart failure
ZHANG Lin1,2， JIAO Jinyu3， LIU Ming3
(1. Wuhan University of Science and Technology Affiliated Wuhan Asia Heart Hospital; 2. Medical School, Medical Department, Wuhan University of Science and Technology, Wuhan Hubei 430022; 3. Department of Heart Function,Wuhan University of Science and Technology Affiliated Wuhan Asia Heart Hospital, Wuhan Hubei 430022, China)
Abstract：At present, many studies have shown that QRS complex duration is not completely linear with ventricular mechanical asynchrony, however, synchronous ventricular electrical activation is an important prerequisite for normal systole and diastolic functions of the ventricle. Patients with chronic heart failure (HF) often have ventricular systolic dysfunction. Although in the early stages of HF, the heart makes adaptive changes, once the compensatory limit is exceeded, it can lead to heart remodeling and serious damage to heart functions. Electrocardiography and mechanical remodeling is influenced by multiple factors such as cardiac structure, and cellular and molecular levels, which is manifested by prolonged QRS complex duration in the ECG. In the treatment of HF, in addition to traditional pacemakers, the emerged conduction system pacing in recent years is more suitable to the characteristics of physiological conduction, not only significantly shortening the QRS complex duration but also significantly improving ventricular mechanical synchronization. This review summarizes the possible mechanisms of electricalmechanical asynchrony in patients with chronic HF, and its relationship with QRS complex duration. It also covers the influence of the two factors on cardiac function.
