Abstract: Objective To explore the diagnostic value of detecting type Ⅰ Brugada wave from high right precordial lead in the diagnosis of Brugada syndrome (BrS). Methods Retrospective analysis was performed on 28 patients with Brugada wave or suspected Brugada wave in routine ECG examination. High right precordial lead was additionally applied in 10 of them (experimental group) while the remained 18 cases only performed routine ECG examination (control group). The incidence of type Ⅰ Brugada wave was compared between the two groups. Results Type Ⅰ Brugada wave is detected in 6 patients of the experimental group, with a detection rate of 60.0% while Brugada wave is found in 4 cases of the contol group, with a detection rate of 22.2%. Conclusion The detection rate of type Ⅰ Brugada wave is higher with high right precordial lead, which provides a necessary condition for BrS diagnosis.