Abstract：Objective To explore the relativity between autonomic nerve function state and human endocrine system function by observing the changes of heart rate variability (HRV) in different time periods of female's menstrual cycle. Methods We selected 62 healthy female volunteers with normal menstrual cycle and 57 days of menstruation as research subjects. The 24-hour ambulatory electrocardiography (AECG) was recorded 35 days before menstruation (luteal phase) and on the third day during menstruation (follicular phase), respectively. The time- and frequency- domain HRV analysis was performed to observe the autonomic nerve function states at different phases of female's menstrual cycle. Results Ninety-seven cases of valid AECG data are obtained among which are 43 cases at the luteal phase (luteal phase group), 54 cases at the follicular phase (follicular phase group), and 35 cases of data valid at both of the two phases. In the follicular phase group, the timedomain HRV indexes of SDNN, SDANN and rMSSD, and frequency-domain HRV indexes of TP, LF and HF are all higher than those in the luteal phase group, without statistically significant difference (P>0.05); self-comparison of 35 cases of AECG data between luteal phase and follicular phase comes to similar results. ConclusionIn female's menstrual cycle, HRV indexes in follicular phase with low hormone secretion level may be higher than those in luteal phase with high hormone secretion level, indicating that autonomic nerve energy in follicular phase tends to increase.
李婷，吴旭芳，武靖，刘小霞，陈了一，崔雪峰，李方洁. 女性生理周期心率变异性反映的自主神经功能状态及意义[J]. 实用心电学杂志, 2021, 30(5): 337-341.
LI Ting1, WU Xufang2, WU Jing3, LIU Xiaoxia4, CHEN Liaoyi5, CUI Xuefeng1, LI Fangjie3. State and significance of autonomic nerve function reflected by heart rate variability in females menstrual cycle. JOURNAL OF PRACTICAL ELECTROCARDIOLOGY, 2021, 30(5): 337-341.
